AK2

Gene Symbol	AK2
Entrez Gene	204
Alt Symbol	ADK2, AK 2
Species	Human
Gene Type	protein-coding
Description	adenylate kinase 2
Other Description	AK 2|ATP-AMP transphosphorylase 2|ATP:AMP phosphotransferase|adenylate kinase 2, mitochondrial|adenylate kinase isoenzyme 2, mitochondrial|adenylate monophosphate kinase
Swissprots	Q5EB54 Q8TCY2 Q8TCY3 B4DHH7 P54819 Q16856 A8K6L1 B4DL64 Q5TIF7
Accessions	EAX07483 EAX07484 EAX07485 EAX07486 P54819 AB005621 BAC16747 AB005622 BAC16748 AB451267 BAG70081 AB451394 BAG70208 AK023758 AK291676 BAF84365 AK295105 BAG58139 AK296863 BAG59426 AK297036 BAG59564 AK307731 AY080899 AAL87027 AY080900 AAL87028 BC009405 AAH09405 BC026705 BC070127 AAH70127 BC090040 AAH90040 BX504559 DB206302 DC422465 U39945 AAC52061 U54645 AAC13881 U84371 AAB41790 XM_011540967 XP_011539269 XR_246248 XR_946575 NM_001199199 NP_001186128 NM_001625 NP_001616 NM_013411 NP_037543 NR_037591 NR_037592
Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP- Rule:MF_03168, ECO:0000269|PubMed:19043416}.
Subcellular Location	Mitochondrion intermembrane space.
Tissue Specificity	Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level). {ECO:0000269|PubMed:19043417}.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AK2 Gene cDNA Clone - orb141729 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-AK2-cDNA-Clone - DC02651 from Abgent, a WuXi AppTec company Prices $322.65 Sizes 10 µg Species Human Accession NM_001625

AK2 - MBS1269280 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC009405

Human AK2 ORF Clone(NM_013411.4) - CDCL153472 from Creative Biomart Species Human Accession NM_013411.4

Human AK2 ORF Clone(NM_001625.3) - CDCL153473 from Creative Biomart Species Human Accession NM_001625.3

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone in cloning vector - HG13146-G from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13146-NY from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13146-NF from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13146-ACG from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG13146-NH from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13146-NM from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13146-CF from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13146-CM from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13146-ACR from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13146-ANR from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG13146-CH from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13146-ANG from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid - HG13146-UT from Sino Biological Species Human

Human AK2 / Adenylate kinase 2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13146-CY from Sino Biological Species Human

Human AK2 ORF clone (NM_001199199.1) - CDCR026178 from Creative biogene Species Human

Human AK2 ORF Clone (BC009405) - CDCS409440 from Creative biogene Species Human Accession P54819

Human AK2 ORF clone (BC009405) - CDCB159577 from Creative biogene Species Human

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