| Gene Symbol | NR2F6 |
|---|---|
| Entrez Gene | 2063 |
| Alt Symbol | EAR-2, EAR2, ERBAL2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear receptor subfamily 2, group F, member 6 |
| Other Description | ERBA-related gene-2|V-erbA-related protein 2|nuclear receptor V-erbA-related|nuclear receptor subfamily 2 group F member 6|v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2 |
| Swissprots | Q9BUE8 Q6P586 Q5XGA0 B2RC68 P10588 |
| Accessions | CAA31282 EAW84580 P10588 AB307712 BAH02303 AK298764 BAG60906 AK314961 BAG37465 BC002669 AAH02669 BC063018 AAH63018 BC084544 AAH84544 HQ692851 ADZ17362 NM_005234 NP_005225 |
| Function | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:18701084}. |
| Tissue Specificity | Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10713182}. |
Mouse/Human/Rat EAR2 / NR2F6 ELISA Kit (Cell-Based ELISA) - LS-F3054 from LifeSpan Bioscience
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Mouse/Human EAR2 / NR2F6 DNA Binding ELISA Kit - LS-F788 from LifeSpan Bioscience
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Human EAR2 ELISA Kit - abx054890 from Abbexa
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Eosinophil Associated Ribonuclease A family Member 2, EAR2, Human, ELISA Kit - E-EL-H1943 from ARP American Research Products
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Eosinophil Associated Ribonuclease A family Member 2, EAR2, Rabbit, ELISA Kit - E-EL-RB0361 from ARP American Research Products
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Eosinophil Associated Ribonuclease A family Member 2, EAR2, Chicken, ELISA Kit - E-EL-Ch1781 from ARP American Research Products
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Eosinophil Associated Ribonuclease A family Member 2, EAR2, Porcine, ELISA Kit - E-EL-P0491 from ARP American Research Products
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Eosinophil Associated Ribonuclease A family Member 2, EAR2, Guinea Pig, ELISA Kit - E-EL-GP0387 from ARP American Research Products
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Eosinophil Associated Ribonuclease A family Member 2, EAR2, Monkey, ELISA Kit - E-EL-MK1503 from ARP American Research Products
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NR2F6 Colorimetric Cell-Based ELISA - CB5837 from Assay Biotechnology
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NR2F6 TFact™ DNA-Binding ELISA - TFE-7118 from Assay Biotechnology
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Human EAR2(Eosinophil Associated Ribonuclease A family Member 2) ELISA Kit - E-EL-H1943 from Elabscience
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Human EAR2 (Eosinophil Associated Ribonuclease A family Member 2) CLIA Kit - E-CL-H1195 from Elabscience
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nuclear receptor subfamily 2, group F, member 6, ELISA Kit - MBS9338754 from MyBioSource
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Human EAR12(Eosinophil Associated Ribonuclease A family Member 12) ELISA Kit - E-EL-H1943 from Iwai North America Inc.
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NR2F6 ELISA Kit - DEIA-XYA1344 from Creative Diagnostics
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NR2F6 ELISA Kit - DEIA-XYA1345 from Creative Diagnostics
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EAR2 - EKH5944 from Nordic BioSite
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Human EAR2 ELISA Kit - E012672 from Biobool
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Human NR2F6 ELISA Kit - E027004 from Biobool
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Human EAR2 / NR2F6 ELISA Kit (Sandwich ELISA) - LS-F36138 from LifeSpan Bioscience
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Human EAR2 / NR2F6 ELISA Kit (CLIA) - LS-F30171 from LifeSpan Bioscience
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NR2F6 Colorimetric Cell-Based ELISA Kit - EKA50704 from Biomatik
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