| Gene Symbol |
NR2F6
|
| Entrez Gene |
2063
|
| Alt Symbol |
EAR-2, EAR2, ERBAL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 2, group F, member 6
|
| Other Description |
ERBA-related gene-2|V-erbA-related protein 2|nuclear receptor V-erbA-related|nuclear receptor subfamily 2 group F member 6|v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2
|
| Swissprots |
Q9BUE8 Q6P586 Q5XGA0 B2RC68 P10588
|
| Accessions |
CAA31282 EAW84580 P10588 AB307712 BAH02303 AK298764 BAG60906 AK314961 BAG37465 BC002669 AAH02669 BC063018 AAH63018 BC084544 AAH84544 HQ692851 ADZ17362 NM_005234 NP_005225
|
| Function |
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:18701084}.
|
| Tissue Specificity |
Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10713182}.
|