Gene Symbol | MRGPRD |
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Entrez Gene | 116512 |
Alt Symbol | MRGD, TGR7 |
Species | Human |
Gene Type | protein-coding |
Description | MAS-related GPR, member D |
Other Description | G-protein coupled receptor TGR7|beta-alanine receptor|mas-related G protein-coupled MRGD|mas-related G-protein coupled receptor member D |
Swissprots | Q8TDS7 Q8NGK7 |
Accessions | BAB89340 BAC06005 Q8TDS7 AB154410 BAD20638 AY427820 AAR05120 BC146427 AAI46428 BC156660 AAI56661 NM_198923 NP_944605 |
Function | May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin- stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:15037633}; Multi-pass membrane protein {ECO:0000269|PubMed:15037633}. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. |
MRGD (C-12) - sc-138439 from Santa Cruz Biotechnology
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MRGD (S-14) - sc-138441 from Santa Cruz Biotechnology
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Anti-GPCR TGR7 antibody - ab65439 from Abcam
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Anti-GPCR TGR7 antibody [EPR10597] - ab155099 from Abcam
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Anti-GPCR TGR7 antibody - Cytoplasmic domain - ab189006 from Abcam
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Anti-MRGD / MRGPRD Antibody (Cytoplasmic Domain) IHC-plus⢠- LS-A4128 from LifeSpan Bioscience
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Anti-MRGD / MRGPRD Antibody (Cytoplasmic Domain) IHC-plus⢠- LS-A4129 from LifeSpan Bioscience
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Anti-MRGD / MRGPRD Antibody (Extracellular Domain) IHC-plus⢠- LS-A4123 from LifeSpan Bioscience
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MRGPRD Antibody - NBP1-91964 from Novus Biologicals
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MRGPRD Antibody - NLS4128 from Novus Biologicals
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MRGPRD Antibody - NBP2-29492 from Novus Biologicals
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Anti-MRGPRD antibody produced in rabbit - SAB2900573 from Sigma-Aldrich
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MRGD antibody - orb85700 from Biorbyt
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MRGPRD Antibody (OALA00795) - OALA00795 from Aviva Systems Biology
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MRGPRD Antibody (OALA00796) - OALA00796 from Aviva Systems Biology
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MRGPRD Antibody (OALA00797) - OALA00797 from Aviva Systems Biology
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MRGD / TGR7 (Cytopl. Dom.) antibody - SP4297P from Acris Antibodies
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MRGD / TGR7 (Cytopl. Dom.) antibody - SP4581P from Acris Antibodies
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Rabbit Anti-Human MRGD / MRGPRD (Cytoplasmic Domain) - 119-10483 from RayBiotech
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Rabbit Anti-Human MRGD / MRGPRD (Extracellular Domain) - 119-10915 from RayBiotech
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Rabbit Anti-Human MRGD / MRGPRD (Cytoplasmic Domain) - 119-10916 from RayBiotech
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Anti- Mas-related G-protein coupled receptor member D Antibody - GWB-AB4194 from Genway Biotech
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Anti- Mas-related G-protein coupled receptor member D Antibody - GWB-60E2E9 from Genway Biotech
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Anti-MRGPRD monoclonal antibody - DCABH-16111 from Creative Diagnostics
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Anti-MRGPRD monoclonal antibody, clone FQS21608 - DCABH-4466 from Creative Diagnostics
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