Gene Symbol | MRGPRD |
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Entrez Gene | 116512 |
Alt Symbol | MRGD, TGR7 |
Species | Human |
Gene Type | protein-coding |
Description | MAS-related GPR, member D |
Other Description | G-protein coupled receptor TGR7|beta-alanine receptor|mas-related G protein-coupled MRGD|mas-related G-protein coupled receptor member D |
Swissprots | Q8TDS7 Q8NGK7 |
Accessions | BAB89340 BAC06005 Q8TDS7 AB154410 BAD20638 AY427820 AAR05120 BC146427 AAI46428 BC156660 AAI56661 NM_198923 NP_944605 |
Function | May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin- stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:15037633}; Multi-pass membrane protein {ECO:0000269|PubMed:15037633}. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. |
MRGD CRISPR/Cas9 KO Plasmid (h) - sc-410263 from Santa Cruz Biotechnology
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MRGD HDR Plasmid (h) - sc-410263-HDR from Santa Cruz Biotechnology
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MRGD Double Nickase Plasmid (h) - sc-410263-NIC from Santa Cruz Biotechnology
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MRGD Double Nickase Plasmid (h2) - sc-410263-NIC-2 from Santa Cruz Biotechnology
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MRGD CRISPR Activation Plasmid (h) - sc-410263-ACT from Santa Cruz Biotechnology
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MRGD CRISPR Activation Plasmid (h2) - sc-410263-ACT-2 from Santa Cruz Biotechnology
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MRGD Lentiviral Activation Particles (h) - sc-410263-LAC from Santa Cruz Biotechnology
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MRGD Lentiviral Activation Particles (h2) - sc-410263-LAC-2 from Santa Cruz Biotechnology
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MRGD siRNA (h) - sc-96591 from Santa Cruz Biotechnology
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MRGD shRNA Plasmid (h) - sc-96591-SH from Santa Cruz Biotechnology
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MRGD shRNA (h) Lentiviral Particles - sc-96591-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN14532 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14532 from Sigma-Aldrich
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MRGPRD siRNA (Human) - CRJ4524 from Cohesion Biosciences
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MRGPRD RNAi - H00116512-R02 from Novus Biologicals
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shRNA set against Human MRGPRD (NM_198923.2) - SHH344356 from Creative biogene
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shRNA set against Human MRGPRD(NM_198923.2) - SHH198479 from Creative biogene
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Human MRGPRD siRNA - orb275025 from Biorbyt
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MRGPRD shRNA Plasmid (Human) - CHJ4524 from Cohesion Biosciences
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MRGPRD miRNA 3'UTR clone - MiUTR1H-06417 from Creative biogene
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