| Gene Symbol |
MRGPRD
|
| Entrez Gene |
116512
|
| Alt Symbol |
MRGD, TGR7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MAS-related GPR, member D
|
| Other Description |
G-protein coupled receptor TGR7|beta-alanine receptor|mas-related G protein-coupled MRGD|mas-related G-protein coupled receptor member D
|
| Swissprots |
Q8TDS7 Q8NGK7
|
| Accessions |
BAB89340 BAC06005 Q8TDS7 AB154410 BAD20638 AY427820 AAR05120 BC146427 AAI46428 BC156660 AAI56661 NM_198923 NP_944605
|
| Function |
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin- stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15037633}; Multi-pass membrane protein {ECO:0000269|PubMed:15037633}. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
|
![Western Blot: MRGD Overexpression Lysate (Adult Normal) [NBP2-04452] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MRGD.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9073_MRGD%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04452-img0001.jpg)