SHC4

Gene Symbol	SHC4
Entrez Gene	399694
Alt Symbol	RaLP, SHCD
Species	Human
Gene Type	protein-coding
Description	SHC (Src homology 2 domain containing) family, member 4
Other Description	SH2 domain protein C4|SHC-transforming protein 4|SHC-transforming protein D|hShcD|rai-like protein|src homology 2 domain-containing-transforming protein C4
Swissprots	Q8IYW3 Q6UXQ3 Q6S5L8
Accessions	Q6S5L8 AK124916 BAG54111 AK125762 BAG54244 AK302156 BAH13639 AW102644 AY358250 AAQ88617 AY464565 AAR19363 BC033907 AAH33907 XM_005254375 XP_005254432 XM_011521552 XP_011519854 NM_203349 NP_976224
Function	Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}.
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.
Tissue Specificity	Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential. {ECO:0000269|PubMed:17409413}.
Top Pathways	Natural killer cell mediated cytotoxicity, Chronic myeloid leukemia, Estrogen signaling pathway, MicroRNAs in cancer, Insulin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Shc4 (K-13) - sc-165482 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SHC4 (phospho) antibody - ab96182 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 antibody - ab57808 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SHC4 antibody - ab173408 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-SHC4 antibody - N-terminal - ab174908 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 antibody - N-terminal - ab135426 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa590-617, AP) - LS-C240749 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa590-617, APC) - LS-C240750 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa590-617, Biotin) - LS-C240751 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa590-617, FITC) - LS-C240752 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa590-617, PE) - LS-C240753 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa352-630) - LS-C186202 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa17-45, Biotin) - LS-C240754 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa97-146) - LS-C152212 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa17-45, APC) - LS-C240755 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa17-45, AP) - LS-C240756 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa17-45, FITC) - LS-C240757 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa590-617, Azide-free, HRP) - LS-C248151 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa17-45, Azide-free, HRP) - LS-C248152 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa17-45, PE) - LS-C240761 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa590-617) - LS-C325092 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa17-45) - LS-C325094 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SHC4 Antibody (aa590-617) - LS-C157932 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

SHC4 Antibody - NBP1-33119 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SHC4 Antibody - H00399694-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

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