SHC4

Gene Symbol SHC4
Entrez Gene 399694
Alt Symbol RaLP, SHCD
Species Human
Gene Type protein-coding
Description SHC (Src homology 2 domain containing) family, member 4
Other Description SH2 domain protein C4|SHC-transforming protein 4|SHC-transforming protein D|hShcD|rai-like protein|src homology 2 domain-containing-transforming protein C4
Swissprots Q8IYW3 Q6UXQ3 Q6S5L8
Accessions Q6S5L8 AK124916 BAG54111 AK125762 BAG54244 AK302156 BAH13639 AW102644 AY358250 AAQ88617 AY464565 AAR19363 BC033907 AAH33907 XM_005254375 XP_005254432 XM_011521552 XP_011519854 NM_203349 NP_976224
Function Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}.
Subcellular Location Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.
Tissue Specificity Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential. {ECO:0000269|PubMed:17409413}.
Top Pathways Natural killer cell mediated cytotoxicity, Chronic myeloid leukemia, Estrogen signaling pathway, MicroRNAs in cancer, Insulin signaling pathway

SHC4 CRISPR/Cas9 KO Plasmid (h) - sc-409451 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHC4 HDR Plasmid (h) - sc-409451-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHC4 Double Nickase Plasmid (h) - sc-409451-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHC4 Double Nickase Plasmid (h2) - sc-409451-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHC4 CRISPR Activation Plasmid (h) - sc-409451-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHC4 CRISPR Activation Plasmid (h2) - sc-409451-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHC4 Lentiviral Activation Particles (h) - sc-409451-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHC4 Lentiviral Activation Particles (h2) - sc-409451-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shc4 siRNA (h) - sc-90080 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Shc4 shRNA Plasmid (h) - sc-90080-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Shc4 shRNA (h) Lentiviral Particles - sc-90080-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU037741 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19293 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19293 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11233 from Sigma-Aldrich

Category miRNA

SHC4 siRNA (Human) - CRJ8059 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SHC4 RNAi - H00399694-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SHC4 - MBS8220894 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SHC4 (NM_203349.3) - SHH407000 from Creative biogene

Category siRNA
Species Reactivities Human

Human SHC4 siRNA - orb278560 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SHC4 shRNA Plasmid (Human) - CHJ8059 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SHC4 miRNA 3'UTR clone - MiUTR4H-TG08046 from Creative biogene

Species Reactivities Human
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