SHC4

Gene Symbol	SHC4
Entrez Gene	399694
Alt Symbol	RaLP, SHCD
Species	Human
Gene Type	protein-coding
Description	SHC (Src homology 2 domain containing) family, member 4
Other Description	SH2 domain protein C4|SHC-transforming protein 4|SHC-transforming protein D|hShcD|rai-like protein|src homology 2 domain-containing-transforming protein C4
Swissprots	Q8IYW3 Q6UXQ3 Q6S5L8
Accessions	Q6S5L8 AK124916 BAG54111 AK125762 BAG54244 AK302156 BAH13639 AW102644 AY358250 AAQ88617 AY464565 AAR19363 BC033907 AAH33907 XM_005254375 XP_005254432 XM_011521552 XP_011519854 NM_203349 NP_976224
Function	Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}.
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.
Tissue Specificity	Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential. {ECO:0000269|PubMed:17409413}.
Top Pathways	Natural killer cell mediated cytotoxicity, Chronic myeloid leukemia, Estrogen signaling pathway, MicroRNAs in cancer, Insulin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SHC4 full length protein - ab166484 from Abcam Category Protein Source Wheat germ Species Human

SHC4 Antibody Blocking Peptide - LS-E6763 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SHC4 Antibody Blocking Peptide - LS-E24192 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SHC4 Protein - H00399694-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SHC4-Antibody-N-term-Blocking-peptide - BP11930a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SHC4 / SHCD - H00399694-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SHC4 / SHCD - H00399694-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SHC4 fusion protein - Ag3336 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SHC4, GST-tagged - SHC4-2656H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human SHC-transforming protein 4(SHC4) - CSB-YP747568HU CSB-EP747568HU CSB-BP747568HU CSB-MP747568HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SHC4 Protein - abx163191 from Abbexa Category Protein Species Human

SHC4 / SHCD - TP306373 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SHC4 Peptide, Human - M34GP14200H from Creative Peptides Category Peptide Source Synthetic. Species Human

SHC4 Recombinant Protein Antigen - NBP2-56379PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SHC-transforming protein 4 (SHC4), Recombinant Protein - MBS1480447 from MyBioSource Category Protein Prices $1,425.00, $1,425.00, $1,655.00, $1,655.00, $2,415.00, $2,415.00, $2,860.00, $2,860.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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