| Gene Symbol |
SHC4
|
| Entrez Gene |
399694
|
| Alt Symbol |
RaLP, SHCD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SHC (Src homology 2 domain containing) family, member 4
|
| Other Description |
SH2 domain protein C4|SHC-transforming protein 4|SHC-transforming protein D|hShcD|rai-like protein|src homology 2 domain-containing-transforming protein C4
|
| Swissprots |
Q8IYW3 Q6UXQ3 Q6S5L8
|
| Accessions |
Q6S5L8 AK124916 BAG54111 AK125762 BAG54244 AK302156 BAH13639 AW102644 AY358250 AAQ88617 AY464565 AAR19363 BC033907 AAH33907 XM_005254375 XP_005254432 XM_011521552 XP_011519854 NM_203349 NP_976224
|
| Function |
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.
|
| Tissue Specificity |
Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential. {ECO:0000269|PubMed:17409413}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity, Chronic myeloid leukemia, Estrogen signaling pathway, MicroRNAs in cancer, Insulin signaling pathway
|