SHC4

Gene Symbol	SHC4
Entrez Gene	399694
Alt Symbol	RaLP, SHCD
Species	Human
Gene Type	protein-coding
Description	SHC (Src homology 2 domain containing) family, member 4
Other Description	SH2 domain protein C4|SHC-transforming protein 4|SHC-transforming protein D|hShcD|rai-like protein|src homology 2 domain-containing-transforming protein C4
Swissprots	Q8IYW3 Q6UXQ3 Q6S5L8
Accessions	Q6S5L8 AK124916 BAG54111 AK125762 BAG54244 AK302156 BAH13639 AW102644 AY358250 AAQ88617 AY464565 AAR19363 BC033907 AAH33907 XM_005254375 XP_005254432 XM_011521552 XP_011519854 NM_203349 NP_976224
Function	Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}.
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.
Tissue Specificity	Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential. {ECO:0000269|PubMed:17409413}.
Top Pathways	Natural killer cell mediated cytotoxicity, Chronic myeloid leukemia, Estrogen signaling pathway, MicroRNAs in cancer, Insulin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SHC4-cDNA-Clone - DC06693 from Abgent, a WuXi AppTec company Prices $850.50 Sizes 10 µg Species Human Accession BC033907

SHC4 - MBS1268298 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC033907

human SHC4 ORF clone - CDCH079966 from Creative Biomart Species Human Accession NM_203349

human SHC4 ORF clone - CDCH079967 from Creative Biomart Species Human Accession NM_203349

human SHC4 ORF clone - CDCH079968 from Creative Biomart Species Human Accession NM_203349

human SHC4 ORF clone - CDCH079969 from Creative Biomart Species Human Accession NM_203349

Human SHC4 Gene ORF cDNA clone in cloning vector - HG14532-G from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, C-His tag - HG14532-CH from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid - HG14532-UT from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14532-ACR from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14532-CY from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14532-ANR from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14532-NF from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14532-CF from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, N-His tag - HG14532-NH from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14532-ANG from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14532-NM from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14532-NY from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14532-CM from Sino Biological Species Human

Human SHC4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14532-ACG from Sino Biological Species Human

human SHC4 ORF clone (NM_203349.3) - CDCH079967 from Creative biogene Species Human

Human SHC4 ORF Clone (BC033907) - CDCS417870 from Creative biogene Species Human Accession Q6S5L8

Human SHC4 ORF clone (BC033907) - CDCB159037 from Creative biogene Species Human

Search more