Gene Symbol | NKIRAS1 |
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Entrez Gene | 28512 |
Alt Symbol | KBRAS1, kappaB-Ras1 |
Species | Human |
Gene Type | protein-coding |
Description | NFKB inhibitor interacting Ras-like 1 |
Other Description | I-kappa-B-interacting Ras-like protein 1|NF-kappa-B inhibitor-interacting Ras-like protein 1|NFKB inhibitor interacting Ras-like protein 1|kappa B-Ras protein 1|kappa B-ras 1 |
Swissprots | Q96K18 Q9NYS0 |
Accessions | ABC40740 CAD34857 EAW64335 EAW64336 Q9NYS0 AF229839 AAF34998 AK027749 BAB55341 BC012145 AAH12145 BC066940 AAH66940 BG713995 EU176465 ABW03916 XM_005265076 XP_005265133 XM_005265077 XP_005265134 XM_005265078 XP_005265135 NM_020345 NP_065078 |
Function | Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. {ECO:0000269|PubMed:10657303, ECO:0000269|PubMed:12672800, ECO:0000269|PubMed:15024091}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15024091}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10657303}. |
κB-Ras1 (184C278) - sc-52915 from Santa Cruz Biotechnology
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κB-Ras1 (C-17) - sc-10525 from Santa Cruz Biotechnology
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κB-Ras1 (L-18) - sc-10524 from Santa Cruz Biotechnology
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Anti-NKIRAS1 antibody - ab83872 from Abcam
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Anti-NKIRAS1 antibody - ab173099 from Abcam
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Anti-NKIRAS1 antibody [184C278] - ab13666 from Abcam
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Anti-NKIRAS1 antibody [8B11] - ab139272 from Abcam
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Anti-NKIRAS1 Antibody (aa179-192) - LS-C18993 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa96-113) - LS-C71221 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa179-192) - LS-C75338 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa48-76, AP) - LS-C264418 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa48-76, Biotin) - LS-C264419 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa48-76, APC) - LS-C264420 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa48-76, FITC) - LS-C264421 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa48-76, Azide-free, HRP) - LS-C264422 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa48-76, PE) - LS-C264426 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa47-76) - LS-C323349 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (Internal) - LS-C19460 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa36-85) - LS-C102621 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa48-76) - LS-C158390 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (clone 8A3) - LS-C174306 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (clone 2A7) - LS-C133733 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (clone 1D2) - LS-C174168 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (C-Terminus) - LS-C19461 from LifeSpan Bioscience
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Anti-NKIRAS1 Antibody (aa96-113, clone 184C278) IHC-plus⢠- LS-B1978 from LifeSpan Bioscience
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