Gene Symbol | NKIRAS1 |
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Entrez Gene | 28512 |
Alt Symbol | KBRAS1, kappaB-Ras1 |
Species | Human |
Gene Type | protein-coding |
Description | NFKB inhibitor interacting Ras-like 1 |
Other Description | I-kappa-B-interacting Ras-like protein 1|NF-kappa-B inhibitor-interacting Ras-like protein 1|NFKB inhibitor interacting Ras-like protein 1|kappa B-Ras protein 1|kappa B-ras 1 |
Swissprots | Q96K18 Q9NYS0 |
Accessions | ABC40740 CAD34857 EAW64335 EAW64336 Q9NYS0 AF229839 AAF34998 AK027749 BAB55341 BC012145 AAH12145 BC066940 AAH66940 BG713995 EU176465 ABW03916 XM_005265076 XP_005265133 XM_005265077 XP_005265134 XM_005265078 XP_005265135 NM_020345 NP_065078 |
Function | Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. {ECO:0000269|PubMed:10657303, ECO:0000269|PubMed:12672800, ECO:0000269|PubMed:15024091}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15024091}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10657303}. |
Human NKIRAS1 full length protein - ab123143 from Abcam
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NKIRAS1 Antibody Blocking Peptide - LS-E5047 from LifeSpan Bioscience
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NKIRAS1 Antibody Blocking Peptide - LS-E29975 from LifeSpan Bioscience
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NKIRAS1 Antibody Blocking Peptide - LS-E29976 from LifeSpan Bioscience
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NKIRAS1 Antibody Blocking Peptide - LS-E20002 from LifeSpan Bioscience
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NKIRAS1 Partial Recombinant Protein - H00028512-Q01 from Novus Biologicals
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NKIRAS1 Blocking Peptide - NBP1-76726PEP from Novus Biologicals
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NKIRAS1 Peptide - NBP1-76725PEP from Novus Biologicals
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Recombinant Human NKIRAS1 Protein - NBP1-99105 from Novus Biologicals
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NKIRAS1-Antibody-Center-Blocking-Peptide - BP17459c from Abgent, a WuXi AppTec company
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Human NKIRAS1 protein - orb168928 from Biorbyt
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NKIRAS1 Blocking Peptide - 33R-1680 from Fitzgerald
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NKIRAS1 protein (His tag) - 80R-2156 from Fitzgerald
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NKIRAS1 (1-192, His-tag) - AR50237PU-N from Acris Antibodies
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NKIRAS1 (1-192, His-tag) - AR50237PU-S from Acris Antibodies
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NKIRAS1 - H00028512-Q01-10 from Acris Antibodies
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NKIRAS1 - H00028512-Q01-25 from Acris Antibodies
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NKIRAS1 - P5848 from Acris Antibodies
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NKIRAS1 Control Peptide - AP30475CP-N from Acris Antibodies
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NKIRAS1 Control Peptide - AP30476CP-N from Acris Antibodies
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NKIRAS1, 1-192aa, Human, His tag, E.coli - 01-P1412 from ARP American Research Products
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KappaB ras Peptide - 2491P from ProSci
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KappaB ras1 Peptide - 2493P from ProSci
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NKIRAS1 fusion protein - Ag5271 from Proteintech Group
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NKIRAS1 fusion protein - Ag5375 from Proteintech Group
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