| Gene Symbol |
NKIRAS1
|
| Entrez Gene |
28512
|
| Alt Symbol |
KBRAS1, kappaB-Ras1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NFKB inhibitor interacting Ras-like 1
|
| Other Description |
I-kappa-B-interacting Ras-like protein 1|NF-kappa-B inhibitor-interacting Ras-like protein 1|NFKB inhibitor interacting Ras-like protein 1|kappa B-Ras protein 1|kappa B-ras 1
|
| Swissprots |
Q96K18 Q9NYS0
|
| Accessions |
ABC40740 CAD34857 EAW64335 EAW64336 Q9NYS0 AF229839 AAF34998 AK027749 BAB55341 BC012145 AAH12145 BC066940 AAH66940 BG713995 EU176465 ABW03916 XM_005265076 XP_005265133 XM_005265077 XP_005265134 XM_005265078 XP_005265135 NM_020345 NP_065078
|
| Function |
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. {ECO:0000269|PubMed:10657303, ECO:0000269|PubMed:12672800, ECO:0000269|PubMed:15024091}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15024091}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10657303}.
|