FTO

Gene Symbol	FTO
Entrez Gene	79068
Alt Symbol	ALKBH9
Species	Human
Gene Type	protein-coding
Description	fat mass and obesity associated
Other Description	AlkB homolog 9|alpha-ketoglutarate-dependent dioxygenase FTO|fat mass and obesity-associated protein|protein fto
Swissprots	Q9C0B1 B2RNS0 A2RUH1 Q7Z785 Q0P676
Accessions	EAW82811 Q9C0B1 AB051539 BAB21843 AK096554 BAG53322 AK295196 BAG58196 BC001284 BC003583 AAH03583 BC030798 AAH30798 BC132892 AAI32893 BC137091 AAI37092 BC148442 AAI48443 BC153032 AAI53033 DA324897 U79260 AAB50206 XM_011523313 XP_011521615 XM_011523314 XP_011521616 XM_011523315 XP_011521617 XM_011523316 XP_011521618 NM_001080432 NP_001073901
Function	Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. {ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22002720}. Nucleus speckle {ECO:0000269|PubMed:22002720}.
Tissue Specificity	Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary. {ECO:0000269|PubMed:17434869, ECO:0000269|PubMed:17496892}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FTO ELISA Kit - 55R-1428 from Fitzgerald Category ELISA Kit Prices $895.00 Sizes 100 assays

FTO ELISA Kit (Mouse) - 55R-1429 from Fitzgerald Category ELISA Kit Prices $895.00 Sizes 100 assays

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), Human, ELISA Kit - E01A1859 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Human FTO ELISA Kit - 68ELH-FTO from RayBiotech Category ELISA Kit

Mouse FTO ELISA Kit - 68ELM-FTO from RayBiotech Category ELISA Kit

Alpha ketoglutae dependent dioxygenase FTO, ELISA Kit - MBS7211544 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alpha ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7228899 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7211560 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7227502 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7221114 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7230853 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7224489 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7207081 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7202483 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7201480 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7202777 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Alpha-ketoglutae-dependent dioxygenase FTO (FTO), ELISA Kit - MBS7201256 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

fat mass and obesity associated, ELISA Kit - MBS9326824 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.25 ng/ml - 8 ng/ml.

FTO (human intracellular) ELISA Kit - K4921-100 from Biovision Category ELISA Kit Prices $795.00 Sizes 100 assays

FTO (mouse intracellular) ELISA Kit - K4922-100 from Biovision Category ELISA Kit Prices $795.00 Sizes 100 assays

Human Alpha-ketoglutarate-dependent dioxygenase FTO ELISA Kit - EKE54442 from Biomatik Category ELISA Kit Prices $759.00, $3,225.75, $6,072.00 Sizes 96 t, 5x96t, 10x96t Range 0.312-20 ng/mL

Human FTO ELISA Kit - E014486 from Biobool Category ELISA Kit Sensitivity 0.1 ng/ml.

FTO ELISA Kit (Human) (OKEH03328) - OKEH03328 from Aviva Systems Biology Category ELISA Kit Prices $455.00 Sizes 96 wells Sensitivity 0.156 ng/mL Range 0.312 - 20 ng/mL

Human Alpha-ketoglutarate-dependent dioxygenase FTO ELISA Kit - EK4628 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Sensitivity less than 0.082ng/mL Range 0.156-10 ng/mL

anti-FTO antibody - ARG64738 from Arigo Biolaboratories Category ELISA Kit

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