FTO

Gene Symbol	FTO
Entrez Gene	79068
Alt Symbol	ALKBH9
Species	Human
Gene Type	protein-coding
Description	fat mass and obesity associated
Other Description	AlkB homolog 9|alpha-ketoglutarate-dependent dioxygenase FTO|fat mass and obesity-associated protein|protein fto
Swissprots	Q9C0B1 B2RNS0 A2RUH1 Q7Z785 Q0P676
Accessions	EAW82811 Q9C0B1 AB051539 BAB21843 AK096554 BAG53322 AK295196 BAG58196 BC001284 BC003583 AAH03583 BC030798 AAH30798 BC132892 AAI32893 BC137091 AAI37092 BC148442 AAI48443 BC153032 AAI53033 DA324897 U79260 AAB50206 XM_011523313 XP_011521615 XM_011523314 XP_011521616 XM_011523315 XP_011521617 XM_011523316 XP_011521618 NM_001080432 NP_001073901
Function	Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. {ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22002720}. Nucleus speckle {ECO:0000269|PubMed:22002720}.
Tissue Specificity	Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary. {ECO:0000269|PubMed:17434869, ECO:0000269|PubMed:17496892}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Alpha-ketoglutarate-dependent dioxygenase FTO Gene - orb92163 from Biorbyt Prices $408.00 Sizes 10 μg Species Human

Human-FTO-cDNA-Clone - DC06161 from Abgent, a WuXi AppTec company Prices $81.00 Sizes 10 µg Species Human Accession BC003583

FTO - MBS1275481 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC030798

FTO - MBS1274742 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC003583

Human FTO ORF clone(NM_001080432.2) - CDCL184326 from Creative Biomart Species Human Accession NM_001080432.2

Human FTO ORF Clone(NM_001080432.2) - CDCL164057 from Creative Biomart Species Human Accession NM_001080432.2

Human FTO ORF clone - CDCL109687 from Creative Biomart Species Human Accession NM_001080432

Human FTO ORF clone - CDCL109688 from Creative Biomart Species Human Accession NM_001080432

Mouse FTO ORF clone - CDCL109689 from Creative Biomart Species Human Accession NM_001080432

Mouse FTO ORF clone - CDCL109690 from Creative Biomart Species Human Accession NM_001080432

Mouse FTO ORF clone - CDCL109691 from Creative Biomart Species Human Accession NM_001080432

Mouse FTO ORF clone - CDCL109692 from Creative Biomart Species Human Accession NM_001080432

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone in cloning vector - HG12125-G from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12125-ACR from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG12125-ANR from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, C-His tag - HG12125-CH from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12125-NF from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12125-NM from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12125-CF from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12125-ACG from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG12125-ANG from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12125-CM from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, C-HA tag - HG12125-CY from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid - HG12125-UT from Sino Biological Species Human

Human Fat mass and obesity associated/FTO Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12125-G-F from Sino Biological Species Human

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