FTO

Gene Symbol FTO
Entrez Gene 79068
Alt Symbol ALKBH9
Species Human
Gene Type protein-coding
Description fat mass and obesity associated
Other Description AlkB homolog 9|alpha-ketoglutarate-dependent dioxygenase FTO|fat mass and obesity-associated protein|protein fto
Swissprots Q9C0B1 B2RNS0 A2RUH1 Q7Z785 Q0P676
Accessions EAW82811 Q9C0B1 AB051539 BAB21843 AK096554 BAG53322 AK295196 BAG58196 BC001284 BC003583 AAH03583 BC030798 AAH30798 BC132892 AAI32893 BC137091 AAI37092 BC148442 AAI48443 BC153032 AAI53033 DA324897 U79260 AAB50206 XM_011523313 XP_011521615 XM_011523314 XP_011521616 XM_011523315 XP_011521617 XM_011523316 XP_011521618 NM_001080432 NP_001073901
Function Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. {ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720}.
Subcellular Location Nucleus {ECO:0000269|PubMed:22002720}. Nucleus speckle {ECO:0000269|PubMed:22002720}.
Tissue Specificity Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary. {ECO:0000269|PubMed:17434869, ECO:0000269|PubMed:17496892}.

Fatso CRISPR/Cas9 KO Plasmid (h) - sc-403708 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fatso HDR Plasmid (h) - sc-403708-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fatso Double Nickase Plasmid (h) - sc-403708-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fatso Double Nickase Plasmid (h2) - sc-403708-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fatso CRISPR Activation Plasmid (h) - sc-403708-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fatso CRISPR Activation Plasmid (h2) - sc-403708-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fatso Lentiviral Activation Particles (h) - sc-403708-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fatso Lentiviral Activation Particles (h2) - sc-403708-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fatso siRNA (h) - sc-75002 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fatso shRNA Plasmid (h) - sc-75002-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fatso shRNA (h) Lentiviral Particles - sc-75002-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU092071 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8982 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8982 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FTO siRNA (Human) - CRJ2288 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FTO - MBS8213136 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FTO (NM_001080432.2) - SHH297549 from Creative biogene

Category siRNA
Species Reactivities Human

FTO shRNA Plasmid (Human) - CHJ2288 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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