FTO

Gene Symbol	FTO
Entrez Gene	79068
Alt Symbol	ALKBH9
Species	Human
Gene Type	protein-coding
Description	fat mass and obesity associated
Other Description	AlkB homolog 9|alpha-ketoglutarate-dependent dioxygenase FTO|fat mass and obesity-associated protein|protein fto
Swissprots	Q9C0B1 B2RNS0 A2RUH1 Q7Z785 Q0P676
Accessions	EAW82811 Q9C0B1 AB051539 BAB21843 AK096554 BAG53322 AK295196 BAG58196 BC001284 BC003583 AAH03583 BC030798 AAH30798 BC132892 AAI32893 BC137091 AAI37092 BC148442 AAI48443 BC153032 AAI53033 DA324897 U79260 AAB50206 XM_011523313 XP_011521615 XM_011523314 XP_011521616 XM_011523315 XP_011521617 XM_011523316 XP_011521618 NM_001080432 NP_001073901
Function	Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. {ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22002720}. Nucleus speckle {ECO:0000269|PubMed:22002720}.
Tissue Specificity	Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary. {ECO:0000269|PubMed:17434869, ECO:0000269|PubMed:17496892}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FTO peptide - ab109634 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human FTO full length protein - ab109039 from Abcam Category Protein Source E. coli Species Human

Mouse FTO full length protein - ab108958 from Abcam Category Protein Source E. coli Species Mouse

Rat FTO full length protein - ab108959 from Abcam Category Protein Source E. coli Species Rat

Rat FTO peptide - ab57007 from Abcam Category Peptide

FTO Antibody Blocking Peptide - LS-E8579 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FTO Antibody Blocking Peptide - LS-E17206 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FTO Antibody Blocking Peptide - LS-E26730 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FTO Antibody Blocking Peptide - LS-E30688 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FTO Blocking Peptide - NB110-60935PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Recombinant Human FTO Protein - H00079068-P01 from Novus Biologicals Category Protein Prices $325.00, $475.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FTO Blocking Peptide - NBP1-77021PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

FTO-Antibody-N-term-Blocking-Peptide - BP6976a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FTO (Mouse) blocking peptide - GTX88551-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat

FTO Peptide - GTX85019-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

FTO peptide - orb218639 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Rabbit, Monkey, Drosophila, Sheep

Fto Blocking Peptide - 33R-6164 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FTO Blocking Peptide - 33R-10037 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FTO Blocking Peptide - abx063970 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Monkey, Pig, Rabbit, Sheep

FTO Peptide - AC21-1568-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FTO - H00079068-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FTO - H00079068-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FTO Control Peptide - AP30350CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

FTO Peptide - 5137P from ProSci Category Peptide Species Human

Recombinant Human FTO, His tagged - FTO-3953H from Creative Biomart Category Protein Source E. coli Species Human

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