IPO11
| Gene Symbol | IPO11 |
|---|---|
| Entrez Gene | 51194 |
| Alt Symbol | RanBP11 |
| Species | Human |
| Gene Type | protein-coding |
| Description | importin 11 |
| Other Description | Ran binding protein 11|imp11|importin-11|ran-binding protein 11 |
| Swissprots | Q9NSJ6 Q9UI26 Q8N5R2 A6NGJ5 B4DZ73 Q9NVB1 D3DW98 |
| Accessions | EAW51379 EAW51380 EAW51381 Q9UI26 AF111109 AAF21936 AK001696 BAA91843 AK023177 BAG51165 AK124969 AK302781 BAG63985 AL162083 CAB82416 AL705962 BC031694 AAH31694 BC033776 AAH33776 BC043163 BM966917 DA473424 DQ894533 ABM85459 EU176274 ABW03725 NM_001134779 NP_001128251 NM_016338 NP_057422 |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11032817}. Nucleus {ECO:0000269|PubMed:11032817}. |
Importin-11 (N-22) - sc-130662 from Santa Cruz Biotechnology
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Anti-IPO11 antibody - ab118415 from Abcam
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Anti-IPO11 antibody - ab102995 from Abcam
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Anti-IPO11 antibody - C-terminal - ab157582 from Abcam
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Anti-IPO11 antibody - N-terminal - ab93475 from Abcam
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Anti-IPO11 / Importin 11 Antibody (aa1-50) - LS-C125754 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa891-920, AP) - LS-C260295 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa891-920, APC) - LS-C260296 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa891-920, Biotin) - LS-C260297 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa1-50) - LS-C47278 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa891-920, FITC) - LS-C260298 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa891-920, Azide-free, HRP) - LS-C260299 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (N-Terminus, AP) - LS-C278311 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa891-920, PE) - LS-C260301 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (N-Terminus, APC) - LS-C278314 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (N-Terminus, Biotin) - LS-C278315 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (N-Terminus, FITC) - LS-C278316 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (N-Terminus) - LS-C327614 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa906-970) - LS-C322257 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (N-Terminus, PE) - LS-C278317 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (N-Terminus, Azide-free, HRP) - LS-C278318 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa328-377) - LS-C170263 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa37-221) - LS-C178636 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa891-920) - LS-C165262 from LifeSpan Bioscience
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Anti-IPO11 / Importin 11 Antibody (aa56-85) - LS-C165263 from LifeSpan Bioscience
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