| Gene Symbol |
IPO11
|
| Entrez Gene |
51194
|
| Alt Symbol |
RanBP11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
importin 11
|
| Other Description |
Ran binding protein 11|imp11|importin-11|ran-binding protein 11
|
| Swissprots |
Q9NSJ6 Q9UI26 Q8N5R2 A6NGJ5 B4DZ73 Q9NVB1 D3DW98
|
| Accessions |
EAW51379 EAW51380 EAW51381 Q9UI26 AF111109 AAF21936 AK001696 BAA91843 AK023177 BAG51165 AK124969 AK302781 BAG63985 AL162083 CAB82416 AL705962 BC031694 AAH31694 BC033776 AAH33776 BC043163 BM966917 DA473424 DQ894533 ABM85459 EU176274 ABW03725 NM_001134779 NP_001128251 NM_016338 NP_057422
|
| Function |
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11032817}. Nucleus {ECO:0000269|PubMed:11032817}.
|
![Western Blot: Importin 11 Overexpression Lysate (Adult Normal) [NBL1-12014] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Importin 11.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3643_Importin%252011%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12014-img0002.jpg)