| Gene Symbol | IPO11 |
|---|---|
| Entrez Gene | 51194 |
| Alt Symbol | RanBP11 |
| Species | Human |
| Gene Type | protein-coding |
| Description | importin 11 |
| Other Description | Ran binding protein 11|imp11|importin-11|ran-binding protein 11 |
| Swissprots | Q9NSJ6 Q9UI26 Q8N5R2 A6NGJ5 B4DZ73 Q9NVB1 D3DW98 |
| Accessions | EAW51379 EAW51380 EAW51381 Q9UI26 AF111109 AAF21936 AK001696 BAA91843 AK023177 BAG51165 AK124969 AK302781 BAG63985 AL162083 CAB82416 AL705962 BC031694 AAH31694 BC033776 AAH33776 BC043163 BM966917 DA473424 DQ894533 ABM85459 EU176274 ABW03725 NM_001134779 NP_001128251 NM_016338 NP_057422 |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11032817}. Nucleus {ECO:0000269|PubMed:11032817}. |
importin 11, ELISA Kit - MBS9317998 from MyBioSource
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Importin 11 (IPO11), ELISA Kit - MBS9313117 from MyBioSource
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Human IPO11 ELISA Kit - E019673 from Biobool
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