| Gene Symbol |
MCM6
|
| Entrez Gene |
4175
|
| Alt Symbol |
MCG40308, Mis5, P105MCM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
minichromosome maintenance complex component 6
|
| Other Description |
DNA replication licensing factor MCM6|MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)|minichromosome maintenance deficient (mis5, S. pombe) 6
|
| Swissprots |
B2R6H2 Q99859 Q13504 Q14566
|
| Accessions |
AAO26043 AAX88925 AAY15028 CAN37618 CDH61697 EAX11621 Q14566 AA577398 AK299236 BAG61268 AK303455 BAG64499 AK312575 BAG35469 AU124893 BC008774 BC020268 BC032374 AAH32374 CN389677 D84557 BAA12699 DA521248 U46838 AAC50766 NM_005915 NP_005906
|
| Function |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. {ECO:0000269|PubMed:9305914}.
|
| Subcellular Location |
Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase.
|
| Top Pathways |
DNA replication, Cell cycle
|
![Western Blot: MCM6 Overexpression Lysate (Adult Normal) [NBL1-12955] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MCM6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9484_MCM6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12955-img0002.jpg)