MCM6

Gene Symbol MCM6
Entrez Gene 4175
Alt Symbol MCG40308, Mis5, P105MCM
Species Human
Gene Type protein-coding
Description minichromosome maintenance complex component 6
Other Description DNA replication licensing factor MCM6|MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)|minichromosome maintenance deficient (mis5, S. pombe) 6
Swissprots B2R6H2 Q99859 Q13504 Q14566
Accessions AAO26043 AAX88925 AAY15028 CAN37618 CDH61697 EAX11621 Q14566 AA577398 AK299236 BAG61268 AK303455 BAG64499 AK312575 BAG35469 AU124893 BC008774 BC020268 BC032374 AAH32374 CN389677 D84557 BAA12699 DA521248 U46838 AAC50766 NM_005915 NP_005906
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. {ECO:0000269|PubMed:9305914}.
Subcellular Location Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase.
Top Pathways DNA replication, Cell cycle

MCM6 (B-4) - sc-55576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCM6 (B-4): sc-55576. Western blot analysis of MCM6 expression in HeLa (A), ALL-SIL (B), MM-142 (C), NIH/3T3 (D), KNRK (E), K-562 (F) and Jurkat (G) whole cell lysates.

MCM6 (G-8) - sc-393463 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCM6 (G-8): sc-393463. Western blot analysis of MCM6 expression in Jurkat (A), HeLa (B), K-562 (C) and ALL-SIL (D) whole cell lysates.

MCM6 (H-8) - sc-393618 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCM6 (H-8): sc-393618. Western blot analysis of MCM6 expression in K-562 (A), Jurkat (B), HeLa (C), ALL-SIL (D), MM-142 (E) and KNRK (F) whole cell lysates.

MCM6 (C-20) - sc-9843 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MCM6 siRNA (h): sc-35885. Western blot analysis of MCM6 expression in non-transfected control (A) and MCM6 siRNA transfected (B) HeLa cells. Blot probed with MCM6 (C-20): sc-9843. α-actinin (H-2): sc-17829 used as specificity and loading control.

MCM6 (D-12) - sc-55577 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCM6 (D-12): sc-55577. Western blot analysis of MCM6 expression in HeLa (A), ALL-SIL (B), MM-142 (C), NIH/3T3 (D), KNRK (E), K-562 (F) and Jurkat (G) whole cell lysates.

MCM6 (H-300) - sc-22781 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MCM6 (H-300): sc-22781. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervical cancer tissue showing nuclear staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

MCM6 (N-19) - sc-9845 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MCM6 (N-19): sc-9845. Western blot analysis of MCM6 expression in ALL-SIL (A) and K-562 (B) whole cell lysates.

MCM6 (1) - sc-135983 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
MCM6 (1): sc-135983. Western blot analysis of MCM6 expression in HeLa (A), A549 (B), K-562 (C) and Ramos (D) whole cell lysates.

Anti-MCM6 antibody - ab123578 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MCM6 antibody (ab123578) at 1/100 dilution + 293 cell line lysate at 35 µg

Anti-MCM6 antibody [EPR17686] - ab201683 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR17686
All lanes : Anti-MCM6 antibody [EPR17686] (ab201683) at 1/1000 dilutionLane 1 : MCF7 (Human breast adenocarcinoma cell line) whole cell lysateLane 2 : HeLa (Human epithelial cells from cervix adenocarcinoma) whole cell lysateLane 3 : Jurkat (Human T cell leukemia cells from peripheral blood) whole cell lysateLane 4 : Human tonsil lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-MCM6 antibody - ChIP Grade - ab184147 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Cross-linked ChIP was performed with HeLa chromatin extract and 5 ug of either normal rabbit IgG (1) or ab184147 (2). The precipitated DNA was detected by PCR with primer set targeting to Myc promoter (1 and 2).

Anti-MCM6 Antibody - LS-C43024 from LifeSpan Bioscience

Prices $520.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of human MCM6 in a RIPA extract of HeLa cells by Western Blotting using Rabbit anti-Human MCM6 (LS-C43024).

Anti-MCM6 Antibody (aa79-109, AP) - LS-C226871 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCM6 Antibody (aa79-109, APC) - LS-C226872 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCM6 Antibody (aa79-109, Biotin) - LS-C226873 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCM6 Antibody (aa79-109, FITC) - LS-C226874 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCM6 Antibody (aa79-109, Azide-free, HRP) - LS-C226876 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCM6 Antibody (aa79-109, PE) - LS-C226878 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCM6 Antibody (C-Terminus) - LS-C31430 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
MCM6 antibody LS-C31430 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-MCM6 Antibody - LS-C192830 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of 293 cell lines, using MCM6 antibody.

Anti-MCM6 Antibody - LS-C308922 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-MCM6 Antibody (aa79-109) - LS-C322914 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCM6 Antibody (Internal) - LS-C345396 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of MCM6 Antibody with human Jurkat Whole Cell lysate.

Anti-MCM6 Antibody (aa80-109) - LS-C164096 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MCM6 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human tonsil tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-MCM6 Antibody (C-Terminus) - LS-C286314 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
Detection of Mouse MCM6 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified goat anti-MCM6 used at a dilution of 1:250. Detection: DAB.
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