| Gene Symbol |
NCKAP1
|
| Entrez Gene |
10787
|
| Alt Symbol |
HEM2, NAP1, NAP125, p125Nap1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NCK-associated protein 1
|
| Other Description |
membrane-associated protein HEM-2|nck-associated protein 1
|
| Swissprots |
Q53Y35 Q53QN5 Q9Y2A7 Q53S94 O60329
|
| Accessions |
AAX93118 AAY24196 EAX10952 EAX10953 EAX10954 EAX10955 EAX10956 EAX10957 Q9Y2A7 AB011159 BAA25513 AB014509 BAA77295 AI215133 AK001291 BAG50887 AK002153 BAG51019 AK292914 BAF85603 BC015025 AAH15025 BT007033 AAP35681 CA314471 DQ893545 ABM84471 DQ893809 ABM84735 XM_006712200 XP_006712263 XM_006712201 XP_006712264 NM_013436 NP_038464 NM_205842 NP_995314
|
| Function |
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.
|
| Top Pathways |
Regulation of actin cytoskeleton
|