NCKAP1

Gene Symbol NCKAP1
Entrez Gene 10787
Alt Symbol HEM2, NAP1, NAP125, p125Nap1
Species Human
Gene Type protein-coding
Description NCK-associated protein 1
Other Description membrane-associated protein HEM-2|nck-associated protein 1
Swissprots Q53Y35 Q53QN5 Q9Y2A7 Q53S94 O60329
Accessions AAX93118 AAY24196 EAX10952 EAX10953 EAX10954 EAX10955 EAX10956 EAX10957 Q9Y2A7 AB011159 BAA25513 AB014509 BAA77295 AI215133 AK001291 BAG50887 AK002153 BAG51019 AK292914 BAF85603 BC015025 AAH15025 BT007033 AAP35681 CA314471 DQ893545 ABM84471 DQ893809 ABM84735 XM_006712200 XP_006712263 XM_006712201 XP_006712264 NM_013436 NP_038464 NM_205842 NP_995314
Function Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.
Subcellular Location Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.
Tissue Specificity Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.
Top Pathways Regulation of actin cytoskeleton

NAP125 CRISPR/Cas9 KO Plasmid (h) - sc-404855 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NAP125 HDR Plasmid (h) - sc-404855-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NAP125 Double Nickase Plasmid (h) - sc-404855-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NAP125 Double Nickase Plasmid (h2) - sc-404855-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NAP125 CRISPR Activation Plasmid (h) - sc-404855-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NAP125 CRISPR Activation Plasmid (h2) - sc-404855-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NAP125 Lentiviral Activation Particles (h) - sc-404855-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NAP125 Lentiviral Activation Particles (h2) - sc-404855-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NAP125 siRNA (h) - sc-94668 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NAP125 shRNA Plasmid (h) - sc-94668-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NAP125 shRNA (h) Lentiviral Particles - sc-94668-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU089271 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15020 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15020 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07171 from Sigma-Aldrich

Category miRNA

NCKAP1 siRNA (Human) - CRH7351 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NCKAP1 (NM_013436.3) - SHH349988 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NCKAP1(NM_205842.1) - SHR000672 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NCKAP1(NM_013436.3) - SHR000726 from Creative biogene

Category siRNA
Species Reactivities Human

Human NCKAP1 siRNA - orb267853 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NCKAP1 shRNA Plasmid (Human) - CHH7351 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NCKAP1 miRNA 3'UTR clone - MiUTR1H-06678 from Creative biogene

Species Reactivities Human

NCKAP1 miRNA 3'UTR clone - MiUTR1H-06679 from Creative biogene

Species Reactivities Human
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