| Gene Symbol |
CD320
|
| Entrez Gene |
51293
|
| Alt Symbol |
8D6, 8D6A, TCBLR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD320 molecule
|
| Other Description |
8D6 antigen|CD320 antigen|FDC-SM-8D6|FDC-signaling molecule 8D6|transcobalamin receptor
|
| Swissprots |
B2RDS5 Q9NPF0 F5H6D3 Q53HF7 D6W668
|
| Accessions |
EAW68936 EAW68939 Q9NPF0 AF161254 AAF61850 AK058014 AK222623 BAD96343 AK315656 BAG38022 AL136652 CAB66587 AL365453 CAB97009 AL365455 CAB97010 AY358420 AAQ88786 BC000668 AAH00668 BC007083 AAH07083 BC036814 CB141050 CR457174 CAG33455 EU831651 ACE87251 NM_001165895 NP_001159367 NM_016579 NP_057663
|
| Function |
Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin. {ECO:0000269|PubMed:11418631, ECO:0000269|PubMed:18779389}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed abundantly on follicular dendritic cells (FDCs). {ECO:0000269|PubMed:10727470}.
|
