Gene Symbol | CD320 |
---|---|
Entrez Gene | 51293 |
Alt Symbol | 8D6, 8D6A, TCBLR |
Species | Human |
Gene Type | protein-coding |
Description | CD320 molecule |
Other Description | 8D6 antigen|CD320 antigen|FDC-SM-8D6|FDC-signaling molecule 8D6|transcobalamin receptor |
Swissprots | B2RDS5 Q9NPF0 F5H6D3 Q53HF7 D6W668 |
Accessions | EAW68936 EAW68939 Q9NPF0 AF161254 AAF61850 AK058014 AK222623 BAD96343 AK315656 BAG38022 AL136652 CAB66587 AL365453 CAB97009 AL365455 CAB97010 AY358420 AAQ88786 BC000668 AAH00668 BC007083 AAH07083 BC036814 CB141050 CR457174 CAG33455 EU831651 ACE87251 NM_001165895 NP_001159367 NM_016579 NP_057663 |
Function | Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin. {ECO:0000269|PubMed:11418631, ECO:0000269|PubMed:18779389}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed abundantly on follicular dendritic cells (FDCs). {ECO:0000269|PubMed:10727470}. |