Gene Symbol | CD320 |
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Entrez Gene | 51293 |
Alt Symbol | 8D6, 8D6A, TCBLR |
Species | Human |
Gene Type | protein-coding |
Description | CD320 molecule |
Other Description | 8D6 antigen|CD320 antigen|FDC-SM-8D6|FDC-signaling molecule 8D6|transcobalamin receptor |
Swissprots | B2RDS5 Q9NPF0 F5H6D3 Q53HF7 D6W668 |
Accessions | EAW68936 EAW68939 Q9NPF0 AF161254 AAF61850 AK058014 AK222623 BAD96343 AK315656 BAG38022 AL136652 CAB66587 AL365453 CAB97009 AL365455 CAB97010 AY358420 AAQ88786 BC000668 AAH00668 BC007083 AAH07083 BC036814 CB141050 CR457174 CAG33455 EU831651 ACE87251 NM_001165895 NP_001159367 NM_016579 NP_057663 |
Function | Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin. {ECO:0000269|PubMed:11418631, ECO:0000269|PubMed:18779389}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed abundantly on follicular dendritic cells (FDCs). {ECO:0000269|PubMed:10727470}. |
8D6 CRISPR/Cas9 KO Plasmid (h) - sc-408877 from Santa Cruz Biotechnology
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8D6 HDR Plasmid (h) - sc-408877-HDR from Santa Cruz Biotechnology
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8D6 Double Nickase Plasmid (h) - sc-408877-NIC from Santa Cruz Biotechnology
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8D6 Double Nickase Plasmid (h2) - sc-408877-NIC-2 from Santa Cruz Biotechnology
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8D6 CRISPR Activation Plasmid (h) - sc-408877-ACT from Santa Cruz Biotechnology
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8D6 CRISPR Activation Plasmid (h2) - sc-408877-ACT-2 from Santa Cruz Biotechnology
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8D6 Lentiviral Activation Particles (h) - sc-408877-LAC from Santa Cruz Biotechnology
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8D6 Lentiviral Activation Particles (h2) - sc-408877-LAC-2 from Santa Cruz Biotechnology
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8D6 siRNA (h) - sc-106884 from Santa Cruz Biotechnology
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8D6 shRNA Plasmid (h) - sc-106884-SH from Santa Cruz Biotechnology
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8D6 shRNA (h) Lentiviral Particles - sc-106884-V from Santa Cruz Biotechnology
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CD320/TCblR/8D6A RNAi - H00051293-R01 from Novus Biologicals
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MISSION® esiRNA - EHU072951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5720 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5720 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02447 from Sigma-Aldrich
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CD320 siRNA (Human) - CRH9670 from Cohesion Biosciences
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CD320 - MBS829157 from MyBioSource
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shRNA set against Human CD320 (NM_016579.3) - SHH258977 from Creative biogene
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CD320 shRNA Plasmid (Human) - CHH9670 from Cohesion Biosciences
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CD320 miRNA 3'UTR clone - MiUTR3H-08490 from Creative biogene
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CD320 miRNA 3'UTR clone - MiUTR3H-08491 from Creative biogene
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