NEIL2

Gene Symbol	NEIL2
Entrez Gene	252969
Alt Symbol	NEH2, NEI2
Species	Human
Gene Type	protein-coding
Description	nei endonuclease VIII-like 2 (E. coli)
Other Description	DNA glycosylase/AP lyase Neil2|DNA-(apurinic or apyrimidinic site) lyase Neil2|endonuclease 8-like 2|endonuclease VIII-like 2|nei homolog 2|nei like 2|nei-like protein 2
Swissprots	Q7Z3Q7 Q8NG52 B4DFR7 Q8N842 Q969S2
Accessions	AAP45052 EAW65623 EAW65624 EAW65625 EAW65626 Q969S2 AB079070 BAC06478 AK056206 BAB71120 AK097389 BAC05030 AK225837 AK294224 BAG57528 AM393587 CAL38464 BC013952 AAH13952 BC013964 AAH13964 BC045822 AAH45822 BX537529 CAD97774 DA205315 DA207321 DB452586 EU832351 ACE87608 EU832436 ACE86921 XM_005272381 XP_005272438 XM_005272382 XP_005272439 XM_005272383 XP_005272440 NM_001135746 NP_001129218 NM_001135747 NP_001129219 NM_001135748 NP_001129220 NM_145043 NP_659480
Function	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO:0000269|PubMed:12097317, ECO:0000269|PubMed:14522990, ECO:0000269|PubMed:15175427, ECO:0000269|PubMed:15339932}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12097317}.
Tissue Specificity	Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver. {ECO:0000269|PubMed:12097317}.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NEIL2 293T Cell Transient Overexpression Lysate(Denatured) - H00252969-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

NEIL2 overexpression lysate - LY427694 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

NEIL2 293 Cell Lysate - 404489 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Escherichia coli

NEIL2 Overexpression Lysate (Denatured) - H00252969-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

NEIL2 Overexpression Lysate (Native) - NBL1-13580 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

NEIL2 Over-expression Lysate Product - GWB-3D2300 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

NEIL2 Overexpression Lysate (Native) - NBP2-09579 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

NEIL2 Overexpression Lysate (Denatured) - H00252969-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human NEIL2 Knockdown Stable Cell Line - CSC-DC010284 from Creative biogene Category Cell Line Species Human

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