NEIL2

Gene Symbol	NEIL2
Entrez Gene	252969
Alt Symbol	NEH2, NEI2
Species	Human
Gene Type	protein-coding
Description	nei endonuclease VIII-like 2 (E. coli)
Other Description	DNA glycosylase/AP lyase Neil2|DNA-(apurinic or apyrimidinic site) lyase Neil2|endonuclease 8-like 2|endonuclease VIII-like 2|nei homolog 2|nei like 2|nei-like protein 2
Swissprots	Q7Z3Q7 Q8NG52 B4DFR7 Q8N842 Q969S2
Accessions	AAP45052 EAW65623 EAW65624 EAW65625 EAW65626 Q969S2 AB079070 BAC06478 AK056206 BAB71120 AK097389 BAC05030 AK225837 AK294224 BAG57528 AM393587 CAL38464 BC013952 AAH13952 BC013964 AAH13964 BC045822 AAH45822 BX537529 CAD97774 DA205315 DA207321 DB452586 EU832351 ACE87608 EU832436 ACE86921 XM_005272381 XP_005272438 XM_005272382 XP_005272439 XM_005272383 XP_005272440 NM_001135746 NP_001129218 NM_001135747 NP_001129219 NM_001135748 NP_001129220 NM_145043 NP_659480
Function	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO:0000269|PubMed:12097317, ECO:0000269|PubMed:14522990, ECO:0000269|PubMed:15175427, ECO:0000269|PubMed:15339932}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12097317}.
Tissue Specificity	Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver. {ECO:0000269|PubMed:12097317}.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NEIL2 CRISPR/Cas9 KO Plasmid (h) - sc-408091 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NEIL2 HDR Plasmid (h) - sc-408091-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NEIL2 Double Nickase Plasmid (h) - sc-408091-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NEIL2 Double Nickase Plasmid (h2) - sc-408091-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NEIL2 CRISPR Activation Plasmid (h) - sc-408091-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NEIL2 CRISPR Activation Plasmid (h2) - sc-408091-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NEIL2 Lentiviral Activation Particles (h) - sc-408091-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NEIL2 Lentiviral Activation Particles (h2) - sc-408091-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NEIL2 siRNA (h) - sc-61168 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NEIL2 shRNA Plasmid (h) - sc-61168-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NEIL2 shRNA (h) Lentiviral Particles - sc-61168-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NEIL2 RNAi - H00252969-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU158461 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15196 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15196 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

NEIL2 siRNA (Human) - CRJ6630 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NEIL2 RNAi - H00252969-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human NEIL2 (NM_145043.2) - SHH351172 from Creative biogene Category siRNA Species Reactivities Human

Human NEIL2 siRNA - orb277131 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NEIL2 shRNA Plasmid (Human) - CHJ6630 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NEIL2 miRNA 3'UTR clone - MiUTR1H-06714 from Creative biogene Species Reactivities Human

NEIL2 miRNA 3'UTR clone - MiUTR1H-06715 from Creative biogene Species Reactivities Human

NEIL2 miRNA 3'UTR clone - MiUTR1H-06716 from Creative biogene Species Reactivities Human

NEIL2 miRNA 3'UTR clone - MiUTR1H-06717 from Creative biogene Species Reactivities Human

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