NEIL2

Gene Symbol	NEIL2
Entrez Gene	252969
Alt Symbol	NEH2, NEI2
Species	Human
Gene Type	protein-coding
Description	nei endonuclease VIII-like 2 (E. coli)
Other Description	DNA glycosylase/AP lyase Neil2|DNA-(apurinic or apyrimidinic site) lyase Neil2|endonuclease 8-like 2|endonuclease VIII-like 2|nei homolog 2|nei like 2|nei-like protein 2
Swissprots	Q7Z3Q7 Q8NG52 B4DFR7 Q8N842 Q969S2
Accessions	AAP45052 EAW65623 EAW65624 EAW65625 EAW65626 Q969S2 AB079070 BAC06478 AK056206 BAB71120 AK097389 BAC05030 AK225837 AK294224 BAG57528 AM393587 CAL38464 BC013952 AAH13952 BC013964 AAH13964 BC045822 AAH45822 BX537529 CAD97774 DA205315 DA207321 DB452586 EU832351 ACE87608 EU832436 ACE86921 XM_005272381 XP_005272438 XM_005272382 XP_005272439 XM_005272383 XP_005272440 NM_001135746 NP_001129218 NM_001135747 NP_001129219 NM_001135748 NP_001129220 NM_145043 NP_659480
Function	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO:0000269|PubMed:12097317, ECO:0000269|PubMed:14522990, ECO:0000269|PubMed:15175427, ECO:0000269|PubMed:15339932}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12097317}.
Tissue Specificity	Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver. {ECO:0000269|PubMed:12097317}.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NEIL2 (H-41) - sc-135243 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

NEIL2 (G-13) - sc-47613 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

NEIL2 (P-19) - sc-47614 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

NEIL2 (2626C2a) - sc-81566 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-NEIL2 antibody - ab21341 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-NEIL2 antibody - ab124106 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NEIL2 antibody - ab56577 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-NEIL2 antibody - ab128657 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NEIL2 antibody [EPR13944] - ab180576 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13944

Anti-NEIL2 Antibody - LS-C73218 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-NEIL2 Antibody (clone 2626C2a) - LS-C184589 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2626C2a

Anti-NEIL2 Antibody (aa67-96, AP) - LS-C246579 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEIL2 Antibody (aa67-96, APC) - LS-C246581 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEIL2 Antibody (aa67-96, Biotin) - LS-C246582 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEIL2 Antibody (aa67-96, FITC) - LS-C246583 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEIL2 Antibody (aa64-113) - LS-C151674 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NEIL2 Antibody (aa67-96, PE) - LS-C246584 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEIL2 Antibody (aa67-96, Azide-free, HRP) - LS-C248897 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEIL2 Antibody (aa66-96) - LS-C323284 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEIL2 Antibody (aa67-96) - LS-C164823 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NEIL2 Antibody (clone 2626C2a) - LS-C342623 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2626C2a

NEIL2 Antibody (1B7) - H00252969-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1B7

NEIL2 Antibody - NBP1-98526 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

NEIL2 Antibody - H00252969-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

NEIL2 Antibody - H00252969-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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