NEIL2

Gene Symbol	NEIL2
Entrez Gene	252969
Alt Symbol	NEH2, NEI2
Species	Human
Gene Type	protein-coding
Description	nei endonuclease VIII-like 2 (E. coli)
Other Description	DNA glycosylase/AP lyase Neil2|DNA-(apurinic or apyrimidinic site) lyase Neil2|endonuclease 8-like 2|endonuclease VIII-like 2|nei homolog 2|nei like 2|nei-like protein 2
Swissprots	Q7Z3Q7 Q8NG52 B4DFR7 Q8N842 Q969S2
Accessions	AAP45052 EAW65623 EAW65624 EAW65625 EAW65626 Q969S2 AB079070 BAC06478 AK056206 BAB71120 AK097389 BAC05030 AK225837 AK294224 BAG57528 AM393587 CAL38464 BC013952 AAH13952 BC013964 AAH13964 BC045822 AAH45822 BX537529 CAD97774 DA205315 DA207321 DB452586 EU832351 ACE87608 EU832436 ACE86921 XM_005272381 XP_005272438 XM_005272382 XP_005272439 XM_005272383 XP_005272440 NM_001135746 NP_001129218 NM_001135747 NP_001129219 NM_001135748 NP_001129220 NM_145043 NP_659480
Function	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO:0000269|PubMed:12097317, ECO:0000269|PubMed:14522990, ECO:0000269|PubMed:15175427, ECO:0000269|PubMed:15339932}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12097317}.
Tissue Specificity	Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver. {ECO:0000269|PubMed:12097317}.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NEIL2 full length protein - ab124545 from Abcam Category Protein Source E. coli Species Human

NEIL2 Antibody Blocking Peptide - LS-E3861 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEIL2 Antibody Blocking Peptide - LS-E23437 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEIL2 Recombinant Protein - H00252969-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NEIL2 Protein - NBP1-99001 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E. coli Species Human

NEIL2-Antibody-N-term-Blocking-Peptide - BP16044a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NEIL2 protein (His tag) - 80R-2266 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

NEIL2 Blocking Peptide - abx161176 from Abbexa Category Peptide Species Human, Rat, Chicken, Monkey

NEIL2 (1-332, His-tag) - AR50350PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

NEIL2 (1-332, His-tag) - AR50350PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

NEIL2 - H00252969-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NEIL2 - H00252969-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NEIL2, 1-332aa, Human, His tag, E.coli - 01-P1526 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

NEIL2 fusion protein - ag1751 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NEIL2 Human - ENPS-614 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Nei Endonuclease VIII-Like 2 Enzyme - BP002528-ENZ-607 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

NEIL2, 1-332aa , Human, His tag, E.coli - GWB-P0512E from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

Recombinant Human Nei Endonuclease VIII-like 2 (E. coli), His-tagged - NEIL2-1963H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Nei Endonuclease VIII-like 2 (E. coli) - NEIL2-2042H from Creative Biomart Category Protein Source E. coli.

Recombinant Human NEIL2, His-tagged - NEIL2-15866H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Nei Endonuclease VIII-like 2 (E. coli) - NEIL2-586H from Creative Biomart Category Protein Source E. coli.

NEIL2 Blocking Peptide - CBP3675 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Rat, Bovine, Monkey

Recombinant Human Endonuclease 8-like 2(NEIL2) - CSB-YP846576HU CSB-EP846576HU CSB-BP846576HU CSB-MP846576HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NEIL2, 1-332aa, Human, His tag, E.coli - ATGP1526 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

NEIL2 (transcript variant 1) - TP300913 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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