| Gene Symbol | NEIL2 |
|---|---|
| Entrez Gene | 252969 |
| Alt Symbol | NEH2, NEI2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nei endonuclease VIII-like 2 (E. coli) |
| Other Description | DNA glycosylase/AP lyase Neil2|DNA-(apurinic or apyrimidinic site) lyase Neil2|endonuclease 8-like 2|endonuclease VIII-like 2|nei homolog 2|nei like 2|nei-like protein 2 |
| Swissprots | Q7Z3Q7 Q8NG52 B4DFR7 Q8N842 Q969S2 |
| Accessions | AAP45052 EAW65623 EAW65624 EAW65625 EAW65626 Q969S2 AB079070 BAC06478 AK056206 BAB71120 AK097389 BAC05030 AK225837 AK294224 BAG57528 AM393587 CAL38464 BC013952 AAH13952 BC013964 AAH13964 BC045822 AAH45822 BX537529 CAD97774 DA205315 DA207321 DB452586 EU832351 ACE87608 EU832436 ACE86921 XM_005272381 XP_005272438 XM_005272382 XP_005272439 XM_005272383 XP_005272440 NM_001135746 NP_001129218 NM_001135747 NP_001129219 NM_001135748 NP_001129220 NM_145043 NP_659480 |
| Function | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO:0000269|PubMed:12097317, ECO:0000269|PubMed:14522990, ECO:0000269|PubMed:15175427, ECO:0000269|PubMed:15339932}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12097317}. |
| Tissue Specificity | Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver. {ECO:0000269|PubMed:12097317}. |
| Top Pathways | Base excision repair |