Gene Symbol | PCBD1 |
---|---|
Entrez Gene | 5092 |
Alt Symbol | DCOH, PCBD, PCD, PHS |
Species | Human |
Gene Type | protein-coding |
Description | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha |
Other Description | 4-alpha-hydroxy-tetrahydropterin dehydratase|6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)|dimerizing cofactor for HNF1|phenylalanine hydroxylase-stimulating protein|pterin-4-alpha-carbinolamine dehydratase |
Swissprots | P61457 |
Accessions | AAA35670 AAA35671 AAA35672 AAA69662 EAW54416 EAW54417 P61457 AA397961 AA736613 AF082858 AAD25732 BC006324 AAH06324 BI548743 BM724638 BQ685076 BQ897536 CR542194 CAG46991 L41559 AAA69663 M83742 XM_005269877 XP_005269934 NM_000281 NP_000272 NM_001289797 NP_001276726 |
Function | Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. |
Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic and/or nuclear. |