COPS2

Gene Symbol	COPS2
Entrez Gene	9318
Alt Symbol	ALIEN, CSN2, SGN2, TRIP15
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 2
Other Description	COP9 constitutive photomorphogenic homolog subunit 2\|COP9 signalosome complex subunit 2\|JAB1-containing signalosome subunit 2\|TR-interacting protein 15\|TRIP-15\|alien homolog\|signalosome subunit 2\|thyroid receptor interacting protein 15\|thyroid receptor-interacting protein 15
Swissprots	Q6FGP4 Q9UNI2 Q9BY54 P61201
Accessions	EAW77364 EAW77365 EAW77366 P61201 AB209799 BAD93036 AF084260 AAC34122 AF100762 AAD43026 AF120268 AAD30269 AF212227 AAK26250 AK222590 BAD96310 AK295598 BAG58487 AK312643 BAG35527 BC012629 AAH12629 BM667648 BX648602 CN281648 CN287009 CR542063 CAG46860 DB059510 EU446744 ABZ92273 EU831466 ACE87153 EU831553 ACE86472 L40388 AAC41734 NM_001143887 NP_001137359 NM_004236 NP_004227
Function	Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269\|PubMed:11285227, ECO:0000269\|PubMed:11337588, ECO:0000269\|PubMed:12628923, ECO:0000269\|PubMed:12732143, ECO:0000269\|PubMed:9535219}.
Subcellular Location	Cytoplasm. Nucleus.

TRIP15 (35) - sc-136446 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

TRIP15 (35): sc-136446. Western blot analysis of TRIP15 expression in HeLa whole cell lysate.

TRIP15 (42) - sc-136511 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

TRIP15 (42): sc-136511. Western blot analysis of TRIP15 expression in HeLa (A), Jurkat (B), NCI-H1299 (C) and Hep G2 (D) whole cell lysates.

TRIP15 (K-20) - sc-28413 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TRIP15 (C-17) - sc-28414 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-TRIP15 antibody - ab116237 from Abcam

Prices	$407.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

Anti-TRIP15 antibody (ab116237) at 0.03 µg/ml + NIH 3T3 lysates (in RIPA buffer) at 30 µgdeveloped using the ECL technique

Anti-TRIP15 antibody - ab4537 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-TRIP15 antibody (ab4537) at 0.03 µg/ml + NIH-3T3 cell lysate at 30 µgdeveloped using the ECL technique

Anti-COPS2 / TRIP15 / ALIEN Antibody (aa1-30) IHC-plus™ - LS-B10680 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-COPS2 / TRIP15 / ALIEN Antibody (aa239-250) - LS-C40595 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody - LS-C11834 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody - LS-C63934 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody - LS-C63933 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody - LS-C83464 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody (aa239-250) - LS-C83746 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody (N-Terminus) - LS-C30138 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody (N-Terminus) - LS-C31053 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody - LS-C128423 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody - LS-C128422 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody (aa1-30, APC) - LS-C255255 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody (aa344-444, clone 10B2308, Azide-free) - LS-C183539 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	10B2308

Anti-COPS2 / TRIP15 / ALIEN Antibody (aa1-30, AP) - LS-C255254 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody (aa1-30, FITC) - LS-C255257 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody (N-Terminus) - LS-C80085 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-COPS2 / TRIP15 / ALIEN Antibody (aa1-30, Biotin) - LS-C255256 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody (aa1-30, PE) - LS-C255259 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COPS2 / TRIP15 / ALIEN Antibody (aa1-30, Azide-free, HRP) - LS-C255258 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

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