COPS2

Gene Symbol COPS2
Entrez Gene 9318
Alt Symbol ALIEN, CSN2, SGN2, TRIP15
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 2
Other Description COP9 constitutive photomorphogenic homolog subunit 2|COP9 signalosome complex subunit 2|JAB1-containing signalosome subunit 2|TR-interacting protein 15|TRIP-15|alien homolog|signalosome subunit 2|thyroid receptor interacting protein 15|thyroid receptor-interacting protein 15
Swissprots Q6FGP4 Q9UNI2 Q9BY54 P61201
Accessions EAW77364 EAW77365 EAW77366 P61201 AB209799 BAD93036 AF084260 AAC34122 AF100762 AAD43026 AF120268 AAD30269 AF212227 AAK26250 AK222590 BAD96310 AK295598 BAG58487 AK312643 BAG35527 BC012629 AAH12629 BM667648 BX648602 CN281648 CN287009 CR542063 CAG46860 DB059510 EU446744 ABZ92273 EU831466 ACE87153 EU831553 ACE86472 L40388 AAC41734 NM_001143887 NP_001137359 NM_004236 NP_004227
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm. Nucleus.

TRIP15 CRISPR/Cas9 KO Plasmid (h) - sc-417559 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIP15 HDR Plasmid (h) - sc-417559-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIP15 Double Nickase Plasmid (h) - sc-417559-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIP15 Double Nickase Plasmid (h2) - sc-417559-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIP15 CRISPR Activation Plasmid (h) - sc-417559-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIP15 CRISPR Activation Plasmid (h2) - sc-417559-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIP15 Lentiviral Activation Particles (h) - sc-417559-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIP15 Lentiviral Activation Particles (h2) - sc-417559-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIP15 siRNA (h) - sc-43546 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIP15 shRNA Plasmid (h) - sc-43546-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIP15 shRNA (h) Lentiviral Particles - sc-43546-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU049411 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6432 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6432 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

COPS2 siRNA (Human) - CRH6164 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COP9 signalosome complex subunit 2 RNAi - H00009318-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

COPS2 - MBS8240874 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COPS2 (NM_004236.3) - SHH267793 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human COPS2(NM_004236.3) - SHG054037 from Creative biogene

Category siRNA
Species Reactivities Human

Human CSN2 siRNA - orb266666 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COPS2 shRNA Plasmid (Human) - CHH6164 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COPS2 miRNA 3'UTR clone - MiUTR1H-02357 from Creative biogene

Species Reactivities Human
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