COPS2

Gene Symbol	COPS2
Entrez Gene	9318
Alt Symbol	ALIEN, CSN2, SGN2, TRIP15
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 2
Other Description	COP9 constitutive photomorphogenic homolog subunit 2|COP9 signalosome complex subunit 2|JAB1-containing signalosome subunit 2|TR-interacting protein 15|TRIP-15|alien homolog|signalosome subunit 2|thyroid receptor interacting protein 15|thyroid receptor-interacting protein 15
Swissprots	Q6FGP4 Q9UNI2 Q9BY54 P61201
Accessions	EAW77364 EAW77365 EAW77366 P61201 AB209799 BAD93036 AF084260 AAC34122 AF100762 AAD43026 AF120268 AAD30269 AF212227 AAK26250 AK222590 BAD96310 AK295598 BAG58487 AK312643 BAG35527 BC012629 AAH12629 BM667648 BX648602 CN281648 CN287009 CR542063 CAG46860 DB059510 EU446744 ABZ92273 EU831466 ACE87153 EU831553 ACE86472 L40388 AAC41734 NM_001143887 NP_001137359 NM_004236 NP_004227
Function	Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm. Nucleus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRIP15 peptide - ab23046 from Abcam Category Peptide Species Human

Human TRIP15 protein fragment - ab160425 from Abcam Category Protein Source Wheat germ Species Human

TRIP15 full length protein - ab131957 from Abcam Category Protein Source Wheat germ

COPS2 / TRIP15 / ALIEN Antibody Blocking Peptide - LS-E2418 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS2 / TRIP15 / ALIEN Antibody Blocking Peptide - LS-E25544 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS2 / TRIP15 / ALIEN Antibody Blocking Peptide - LS-E12098 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS2 / TRIP15 / ALIEN Antibody Blocking Peptide - LS-E12099 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSN2 / Beta Casein Antibody Blocking Peptide - LS-E1851 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human COP9 signalosome complex subunit 2 Protein - H00009318-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human COP9 signalosome complex subunit 2 Protein - H00009318-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

beta Casein Partial Recombinant Protein - H00001447-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human beta Casein Protein - NBP1-99089 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E. coli Species Human

beta Casein Recombinant Protein - P5011 from Novus Biologicals Category Protein Prices $669.00 Sizes 50 µg Species Human

COPS2-Antibody-N-term-Blocking-peptide - BP13429a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRIP15 blocking peptide - GTX24537-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Human CSN2 protein - orb168162 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

TRIP15 Peptide - AC21-0373-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

COPS2 / TRIP15 - H00001447-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

COPS2 / TRIP15 - H00001447-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

COPS2 / TRIP15 - H00009318-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

COPS2 / TRIP15 - H00009318-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

COPS2 / TRIP15 - H00009318-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

COPS2 / TRIP15 - H00009318-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

COPS2 Peptide - 45-418P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

COPS2 fusion protein - Ag1415 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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