PTHLH

Gene Symbol PTHLH
Entrez Gene 5744
Alt Symbol BDE2, HHM, PLP, PTHR, PTHRP
Species Human
Gene Type protein-coding
Description parathyroid hormone-like hormone
Other Description PTH-rP|PTH-related protein|osteostatin|parathyroid hormone-like hormone preproprotein|parathyroid hormone-like related protein|parathyroid hormone-related protein
Swissprots Q6FH74 P12272 Q15251
Accessions AAA60221 AAA60358 AAA60359 AAA60360 CAA32480 EAW96572 EAW96573 EAW96574 EAW96575 EAW96576 P12272 AI569027 AI591151 AI760061 AK313476 BAG36261 BC005961 AAH05961 BG676028 BG679319 BG680355 BI752853 BI963162 BT007178 AAP35842 CR541882 CAG46680 DQ896393 ABM87392 EU176428 ABW03879 J03580 AAA60216 J03802 AAA60218 M26958 AAO49791 M26959 AAO49793 M26960 AAN76483 M34071 AAA60217 XM_011520774 XP_011519076 XM_011520775 XP_011519077 NM_002820 NP_002811 NM_198964 NP_945315 NM_198965 NP_945316 NM_198966 NP_945317
Function Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1- dependent manner through activation of Rac1. {ECO:
Subcellular Location Cytoplasm. Nucleus. Secreted.
Tissue Specificity Ubiquitous. Also expressed in the mammary gland.

PTH-rP (1D1) - sc-53936 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PTH-rP (1D1): sc-53936. Western blot analysis of PTH-rP expression in MCF7 whole cell lysate. Kindly provided by Beijing Protein Institute.

PTH-rP (H-137) - sc-20728 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PTH-rP (H-137): sc-20728. Western blot analysis of PTH-rP expression in 3T3-L1 (A), NIH/3T3 (B) and MCF7 (C) whole cell lysates.

PTH-rP (N-19) - sc-9680 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PTH-rP (N-19): sc-9680. Western blot analysis of PTH-rP expression in 3T3-L1 whole cell lysate.

Anti-Parathyroid hormone related protein antibody - ab85205 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Parathyroid hormone related protein antibody (ab85205) at 1/50 dilution + mouse spleen tissue lysate at 35 µg

Anti-Parathyroid hormone related protein antibody - ab82798 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Parathyroid hormone related protein antibody [3D1.1] - ab79539 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D1.1

Anti-Parathyroid hormone related protein antibody (Biotin) - ab82799 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PTHLH antibody - ab55631 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HepG2 cells stained with ab55631 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab55631, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2b [PLPV219] (ab91366, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HepG2 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-PTHLH antibody - ab197358 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling PTHLH with ab197358 at 1/20 dilution.

Anti-PTHLH antibody - ab14199 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PTHLH antibody - ab14178 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PTHLH antibody - ab14179 from Abcam

Prices $0.00
Sizes 50 µl
Host Sheep
Clonality Polyclonal

Anti-PTHLH antibody [3H1-5G8] - ab115488 from Abcam

Host Mouse
Clonality Monoclonal
Clone 3H1-5G8
ab115488, at 5µg/ml, staining PTHLH in Formalin-fixed, Paraffin-embedded Human uterus tissue by Immunohistochemistry.

Anti-PTHLH / PTHRP Antibody (aa107-111) - LS-C37932 from LifeSpan Bioscience

Prices $375.00
Sizes 20 µl
Host Rabbit
Clonality Polyclonal

Anti-PTHLH / PTHRP Antibody - LS-C131234 from LifeSpan Bioscience

Prices $415.00
Sizes 20 µl
Host Rabbit
Clonality Polyclonal

Anti-PTHLH / PTHRP Antibody (aa143-147) - LS-C131235 from LifeSpan Bioscience

Prices $415.00
Sizes 20 µl
Host Sheep
Clonality Polyclonal

Anti-PTHLH / PTHRP Antibody (aa45-59) - LS-C131237 from LifeSpan Bioscience

Prices $415.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-PTHLH / PTHRP Antibody (aa93-107) - LS-C131297 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PTHLH / PTHRP Antibody (aa93-107) - LS-C131296 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PTHLH / PTHRP Antibody (aa53-86) - LS-C131300 from LifeSpan Bioscience

Prices $385.00
Sizes 20 µl
Host Goat
Clonality Polyclonal

Anti-PTHLH / PTHRP Antibody (aa37-175, clone TS106) - LS-C191477 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TS106

Anti-PTHLH / PTHRP Antibody (aa37-177) - LS-C295767 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PTHLH / PTHRP Antibody (aa38-176, Biotin) - LS-C297076 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PTHLH / PTHRP Antibody (aa37-177, Biotin) - LS-C297077 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PTHLH / PTHRP Antibody (aa37-177, Biotin) - LS-C300636 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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