PTHLH
| Gene Symbol | PTHLH |
|---|---|
| Entrez Gene | 5744 |
| Alt Symbol | BDE2, HHM, PLP, PTHR, PTHRP |
| Species | Human |
| Gene Type | protein-coding |
| Description | parathyroid hormone-like hormone |
| Other Description | PTH-rP|PTH-related protein|osteostatin|parathyroid hormone-like hormone preproprotein|parathyroid hormone-like related protein|parathyroid hormone-related protein |
| Swissprots | Q6FH74 P12272 Q15251 |
| Accessions | AAA60221 AAA60358 AAA60359 AAA60360 CAA32480 EAW96572 EAW96573 EAW96574 EAW96575 EAW96576 P12272 AI569027 AI591151 AI760061 AK313476 BAG36261 BC005961 AAH05961 BG676028 BG679319 BG680355 BI752853 BI963162 BT007178 AAP35842 CR541882 CAG46680 DQ896393 ABM87392 EU176428 ABW03879 J03580 AAA60216 J03802 AAA60218 M26958 AAO49791 M26959 AAO49793 M26960 AAN76483 M34071 AAA60217 XM_011520774 XP_011519076 XM_011520775 XP_011519077 NM_002820 NP_002811 NM_198964 NP_945315 NM_198965 NP_945316 NM_198966 NP_945317 |
| Function | Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1- dependent manner through activation of Rac1. {ECO: |
| Subcellular Location | Cytoplasm. Nucleus. Secreted. |
| Tissue Specificity | Ubiquitous. Also expressed in the mammary gland. |
PTH-rP CRISPR/Cas9 KO Plasmid (h) - sc-401209 from Santa Cruz Biotechnology
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PTH-rP HDR Plasmid (h) - sc-401209-HDR from Santa Cruz Biotechnology
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PTH-rP Double Nickase Plasmid (h) - sc-401209-NIC from Santa Cruz Biotechnology
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PTH-rP Double Nickase Plasmid (h2) - sc-401209-NIC-2 from Santa Cruz Biotechnology
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PTH-rP CRISPR Activation Plasmid (h) - sc-401209-ACT from Santa Cruz Biotechnology
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PTH-rP CRISPR Activation Plasmid (h2) - sc-401209-ACT-2 from Santa Cruz Biotechnology
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PTH-rP Lentiviral Activation Particles (h) - sc-401209-LAC from Santa Cruz Biotechnology
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PTH-rP Lentiviral Activation Particles (h2) - sc-401209-LAC-2 from Santa Cruz Biotechnology
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PTH-rP siRNA (h) - sc-39695 from Santa Cruz Biotechnology
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PTH-rP shRNA Plasmid (h) - sc-39695-SH from Santa Cruz Biotechnology
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PTH-rP shRNA (h) Lentiviral Particles - sc-39695-V from Santa Cruz Biotechnology
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PTHLH/PTHrP RNAi - H00005744-R02 from Novus Biologicals
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PTHLH/PTHrP RNAi - H00005744-R04 from Novus Biologicals
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PTHLH/PTHrP RNAi - H00005744-R03 from Novus Biologicals
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MISSION® esiRNA - EHU122941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17681 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08012 from Sigma-Aldrich
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PTHLH siRNA (Human) - CRH3886 from Cohesion Biosciences
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PTHLH/PTHrP RNAi - H00005744-R01 from Novus Biologicals
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shRNA set against Human PTHLH (NM_002820.2) - SHH386208 from Creative biogene
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shRNA set against Human PTHLH(NM_198965.1) - SHR150336 from Creative biogene
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shRNA set against Human PTHLH(NM_002820.2) - SHR150826 from Creative biogene
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shRNA set against Human PTHLH(NM_198965.1) - SHR150880 from Creative biogene
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PTHLH shRNA Plasmid (Human) - CHH3886 from Cohesion Biosciences
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