| Gene Symbol | PTHLH |
|---|---|
| Entrez Gene | 5744 |
| Alt Symbol | BDE2, HHM, PLP, PTHR, PTHRP |
| Species | Human |
| Gene Type | protein-coding |
| Description | parathyroid hormone-like hormone |
| Other Description | PTH-rP|PTH-related protein|osteostatin|parathyroid hormone-like hormone preproprotein|parathyroid hormone-like related protein|parathyroid hormone-related protein |
| Swissprots | Q6FH74 P12272 Q15251 |
| Accessions | AAA60221 AAA60358 AAA60359 AAA60360 CAA32480 EAW96572 EAW96573 EAW96574 EAW96575 EAW96576 P12272 AI569027 AI591151 AI760061 AK313476 BAG36261 BC005961 AAH05961 BG676028 BG679319 BG680355 BI752853 BI963162 BT007178 AAP35842 CR541882 CAG46680 DQ896393 ABM87392 EU176428 ABW03879 J03580 AAA60216 J03802 AAA60218 M26958 AAO49791 M26959 AAO49793 M26960 AAN76483 M34071 AAA60217 XM_011520774 XP_011519076 XM_011520775 XP_011519077 NM_002820 NP_002811 NM_198964 NP_945315 NM_198965 NP_945316 NM_198966 NP_945317 |
| Function | Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1- dependent manner through activation of Rac1. {ECO: |
| Subcellular Location | Cytoplasm. Nucleus. Secreted. |
| Tissue Specificity | Ubiquitous. Also expressed in the mammary gland. |
Human PTHLH / PTHRP ELISA Kit - LS-F4270 from LifeSpan Bioscience
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Rat PTHLH / PTHRP EIA Kit - LS-F4271 from LifeSpan Bioscience
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Mouse PTHLH / PTHRP ELISA Kit (Sandwich ELISA) - LS-F4272 from LifeSpan Bioscience
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Bovine PTHLH / PTHRP ELISA Kit (Sandwich ELISA) - LS-F8817 from LifeSpan Bioscience
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PTH / Parathyroid Hormone EIA Kit - RAB0412 from Sigma-Aldrich
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Parathyroid Hormone Related Protein (PTHrP), Human, ELISA Kit - SEA819Hu from ARP American Research Products
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Parathyroid hormone-related protein, PTHLH, Human, ELISA Kit - E0819h from ARP American Research Products
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PTHrP (Parathyroid Hormone Related Protein), Human, ELISA Kit - E-EL-H1478 from ARP American Research Products
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Parathyroid Hormone Related Protein, PTHrP, Mouse, ELISA Kit - E-EL-M0882 from ARP American Research Products
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Parathyroid Hormone Related Protein, PTHRP, Rat, ELISA Kit - E-EL-R0716 from ARP American Research Products
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Parathyroid Hormone Related Protein, PTHrP, Rabbit, ELISA Kit - E-EL-RB0116 from ARP American Research Products
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Parathyroid Hormone Related Protein, PTHrP, Chicken, ELISA Kit - E-EL-Ch1318 from ARP American Research Products
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Parathyroid Hormone Related Protein, PTHrP, Porcine, ELISA Kit - E-EL-P0299 from ARP American Research Products
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Parathyroid Hormone Related Protein, PTHrP, Guinea Pig, ELISA Kit - E-EL-GP0229 from ARP American Research Products
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Parathyroid Hormone Related Protein, PTHrP, Monkey, ELISA Kit - E-EL-MK0838 from ARP American Research Products
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Human PTHRP ELISA Kit - HP0581 from NeoScientific
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Anserine PTHrP ELISA Kit - AP0581 from NeoScientific
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Pahyroid Hormone Related Protein (PTHrP), ELISA Kit - MBS9308122 from MyBioSource
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PaMonkeyhyroid Hormone-Like Related Protein (PTHrP), ELISA Kit - MBS9300014 from MyBioSource
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PTH-RP ( 1-34 ) ( human, rat, mouse ) ELISA Kit - DEIA2034 from Creative Diagnostics
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Human PTHrP(Parathyroid Hormone Related Protein) ELISA Kit - E-EL-H1478 from Elabscience
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Human PTHrP (Parathyroid Hormone Related Protein) CLIA Kit - E-CL-H0953 from Elabscience
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Parathyroid Hormone Related Protein, ELISA Kit - MBS100628 from MyBioSource
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Parathyroid Hormone Related Protein, ELISA Kit - MBS083534 from MyBioSource
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Parathyroid Hormone Related Protein, ELISA Kit - MBS078429 from MyBioSource
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