| Gene Symbol |
SPI1
|
| Entrez Gene |
6688
|
| Alt Symbol |
OF, PU.1, SFPI1, SPI-1, SPI-A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Spi-1 proto-oncogene
|
| Other Description |
31 kDa transforming protein|31 kDa-transforming protein|hematopoietic transcription factor PU.1|spleen focus forming virus (SFFV) proviral integration oncogene spi1|transcription factor PU.1
|
| Swissprots |
P17947
|
| Accessions |
AAC50247 CDL93508 EAW67924 EAW67925 EAW67926 P17947 AK310065 BC111379 AAI11380 BI519776 BI909430 BM561863 BP271276 CD368431 HG503768 HG503769 HG503770 X52056 CAA36281 XM_011520305 XP_011518607 XM_011520306 XP_011518608 XM_011520307 XP_011518609 XM_011520308 XP_011518610 NM_001080547 NP_001074016 NM_003120 NP_003111
|
| Function |
Binds to the PU-box, a purine-rich DNA sequence (5'- GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00237, ECO:0000269|PubMed:23166356}.
|
| Top Pathways |
Acute myeloid leukemia, Osteoclast differentiation, HTLV-I infection, Epstein-Barr virus infection, Transcriptional misregulation in cancer
|
![Western Blot: PU.1/Spi1 Overexpression Lysate (Adult Normal) [NBP2-10658] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PU.1/Spi1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2178_PU.1-Spi1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10658-img0001.jpg)