Gene Symbol | SPI1 |
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Entrez Gene | 6688 |
Alt Symbol | OF, PU.1, SFPI1, SPI-1, SPI-A |
Species | Human |
Gene Type | protein-coding |
Description | Spi-1 proto-oncogene |
Other Description | 31 kDa transforming protein|31 kDa-transforming protein|hematopoietic transcription factor PU.1|spleen focus forming virus (SFFV) proviral integration oncogene spi1|transcription factor PU.1 |
Swissprots | P17947 |
Accessions | AAC50247 CDL93508 EAW67924 EAW67925 EAW67926 P17947 AK310065 BC111379 AAI11380 BI519776 BI909430 BM561863 BP271276 CD368431 HG503768 HG503769 HG503770 X52056 CAA36281 XM_011520305 XP_011518607 XM_011520306 XP_011518608 XM_011520307 XP_011518609 XM_011520308 XP_011518610 NM_001080547 NP_001074016 NM_003120 NP_003111 |
Function | Binds to the PU-box, a purine-rich DNA sequence (5'- GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00237, ECO:0000269|PubMed:23166356}. |
Top Pathways | Acute myeloid leukemia, Osteoclast differentiation, HTLV-I infection, Epstein-Barr virus infection, Transcriptional misregulation in cancer |
Human SPI1 cDNA clone(NM_001080547.1) - CDFH018488 from Creative Biomart
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Human SPI1 cDNA clone(NM_003120.2) - CDFH018490 from Creative Biomart
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Human SPI1 ORF Clone(NM_003120.2) - CDCR284904 from Creative Biomart
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Human SPI1 ORF Clone(NM_003120.2) - CDCR284905 from Creative Biomart
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Human SPI1 ORF Clone(NM_001080547.1) - CDCR345836 from Creative Biomart
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Human SPI1 ORF Clone(NM_001080547.1) - CDCR345837 from Creative Biomart
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human SPI1 ORF clone - CDCH079232 from Creative Biomart
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human SPI1 ORF clone - CDCH079233 from Creative Biomart
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human SPI1 ORF clone - CDCH079234 from Creative Biomart
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human SPI1 ORF clone - CDCH079235 from Creative Biomart
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human SPI1 ORF clone - CDCH079236 from Creative Biomart
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human SPI1 ORF clone - CDCH079237 from Creative Biomart
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Human SPI1 ORF Clone(NM_003120.2) - CDCL176854 from Creative Biomart
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human SPI1 ORF clone (NM_001080547.1) - CDCH079234 from Creative biogene
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human SPI1 ORF clone (NM_003120.2) - CDCH079236 from Creative biogene
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Human SPI1 cDNA Clone(NM_001080547.1) - CDFH018488 from Creative biogene
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Human SPI1 cDNA Clone(NM_003120.2) - CDFH018490 from Creative biogene
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