SPI1

Gene Symbol SPI1
Entrez Gene 6688
Alt Symbol OF, PU.1, SFPI1, SPI-1, SPI-A
Species Human
Gene Type protein-coding
Description Spi-1 proto-oncogene
Other Description 31 kDa transforming protein|31 kDa-transforming protein|hematopoietic transcription factor PU.1|spleen focus forming virus (SFFV) proviral integration oncogene spi1|transcription factor PU.1
Swissprots P17947
Accessions AAC50247 CDL93508 EAW67924 EAW67925 EAW67926 P17947 AK310065 BC111379 AAI11380 BI519776 BI909430 BM561863 BP271276 CD368431 HG503768 HG503769 HG503770 X52056 CAA36281 XM_011520305 XP_011518607 XM_011520306 XP_011518608 XM_011520307 XP_011518609 XM_011520308 XP_011518610 NM_001080547 NP_001074016 NM_003120 NP_003111
Function Binds to the PU-box, a purine-rich DNA sequence (5'- GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00237, ECO:0000269|PubMed:23166356}.
Top Pathways Acute myeloid leukemia, Osteoclast differentiation, HTLV-I infection, Epstein-Barr virus infection, Transcriptional misregulation in cancer

PU.1 (Spi-1) CRISPR/Cas9 KO Plasmid (h) - sc-400547 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PU.1 (Spi-1) HDR Plasmid (h) - sc-400547-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PU.1 (Spi-1) Double Nickase Plasmid (h) - sc-400547-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PU.1 (Spi-1) Double Nickase Plasmid (h2) - sc-400547-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PU.1 (Spi-1) CRISPR Activation Plasmid (h) - sc-400547-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PU.1 (Spi-1) CRISPR Activation Plasmid (h2) - sc-400547-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PU.1 (Spi-1) Lentiviral Activation Particles (h) - sc-400547-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PU.1 (Spi-1) Lentiviral Activation Particles (h2) - sc-400547-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PU.1 siRNA (h) - sc-36330 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PU.1 shRNA Plasmid (h) - sc-36330-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PU.1 shRNA (h) Lentiviral Particles - sc-36330-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PU.1/Spi-1 RNAi - H00006688-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN20469 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20469 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SPI1 siRNA (Human) - CRH4558 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPI1 - MBS8224831 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PU.1 (Spi-1) CRISPR/Cas9 KO Plasmid (h2) - sc-400547-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PU.1 (Spi-1) HDR Plasmid (h2) - sc-400547-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human SPI1 (NM_003120.2) - SHH416640 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPI1(NM_001080547.1) - SHR219664 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPI1(NM_003120.2) - SHR219720 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPI1(NM_001080547.1) - SHR219784 from Creative biogene

Category siRNA
Species Reactivities Human

Human SPI1 siRNA - orb265060 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPI1 shRNA Plasmid (Human) - CHH4558 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPI1 miRNA 3'UTR clone - MiUTR1H-09836 from Creative biogene

Species Reactivities Human
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