Gene Symbol | SPI1 |
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Entrez Gene | 6688 |
Alt Symbol | OF, PU.1, SFPI1, SPI-1, SPI-A |
Species | Human |
Gene Type | protein-coding |
Description | Spi-1 proto-oncogene |
Other Description | 31 kDa transforming protein|31 kDa-transforming protein|hematopoietic transcription factor PU.1|spleen focus forming virus (SFFV) proviral integration oncogene spi1|transcription factor PU.1 |
Swissprots | P17947 |
Accessions | AAC50247 CDL93508 EAW67924 EAW67925 EAW67926 P17947 AK310065 BC111379 AAI11380 BI519776 BI909430 BM561863 BP271276 CD368431 HG503768 HG503769 HG503770 X52056 CAA36281 XM_011520305 XP_011518607 XM_011520306 XP_011518608 XM_011520307 XP_011518609 XM_011520308 XP_011518610 NM_001080547 NP_001074016 NM_003120 NP_003111 |
Function | Binds to the PU-box, a purine-rich DNA sequence (5'- GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00237, ECO:0000269|PubMed:23166356}. |
Top Pathways | Acute myeloid leukemia, Osteoclast differentiation, HTLV-I infection, Epstein-Barr virus infection, Transcriptional misregulation in cancer |
PU.1 (Spi-1) CRISPR/Cas9 KO Plasmid (h) - sc-400547 from Santa Cruz Biotechnology
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PU.1 (Spi-1) HDR Plasmid (h) - sc-400547-HDR from Santa Cruz Biotechnology
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PU.1 (Spi-1) Double Nickase Plasmid (h) - sc-400547-NIC from Santa Cruz Biotechnology
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PU.1 (Spi-1) Double Nickase Plasmid (h2) - sc-400547-NIC-2 from Santa Cruz Biotechnology
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PU.1 (Spi-1) CRISPR Activation Plasmid (h) - sc-400547-ACT from Santa Cruz Biotechnology
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PU.1 (Spi-1) CRISPR Activation Plasmid (h2) - sc-400547-ACT-2 from Santa Cruz Biotechnology
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PU.1 (Spi-1) Lentiviral Activation Particles (h) - sc-400547-LAC from Santa Cruz Biotechnology
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PU.1 (Spi-1) Lentiviral Activation Particles (h2) - sc-400547-LAC-2 from Santa Cruz Biotechnology
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PU.1 siRNA (h) - sc-36330 from Santa Cruz Biotechnology
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PU.1 shRNA Plasmid (h) - sc-36330-SH from Santa Cruz Biotechnology
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PU.1 shRNA (h) Lentiviral Particles - sc-36330-V from Santa Cruz Biotechnology
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PU.1/Spi-1 RNAi - H00006688-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN20469 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20469 from Sigma-Aldrich
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SPI1 siRNA (Human) - CRH4558 from Cohesion Biosciences
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SPI1 - MBS8224831 from MyBioSource
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PU.1 (Spi-1) CRISPR/Cas9 KO Plasmid (h2) - sc-400547-KO-2 from Santa Cruz Biotechnology
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PU.1 (Spi-1) HDR Plasmid (h2) - sc-400547-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human SPI1 (NM_003120.2) - SHH416640 from Creative biogene
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shRNA set against Human SPI1(NM_001080547.1) - SHR219664 from Creative biogene
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shRNA set against Human SPI1(NM_003120.2) - SHR219720 from Creative biogene
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shRNA set against Human SPI1(NM_001080547.1) - SHR219784 from Creative biogene
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Human SPI1 siRNA - orb265060 from Biorbyt
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SPI1 shRNA Plasmid (Human) - CHH4558 from Cohesion Biosciences
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SPI1 miRNA 3'UTR clone - MiUTR1H-09836 from Creative biogene
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