| Gene Symbol | HTATIP2 |
|---|---|
| Entrez Gene | 10553 |
| Alt Symbol | CC3, SDR44U1, TIP30 |
| Species | Human |
| Gene Type | protein-coding |
| Description | HIV-1 Tat interactive protein 2, 30kDa |
| Other Description | 30 kDa HIV-1 TAT-interacting protein|HIV-1 TAT-interactive protein 2|Tat-interacting protein (30kD)|oxidoreductase HTATIP2|short chain dehydrogenase/reductase family 44U, member 1 |
| Swissprots | O95345 D3DQY8 Q9BUP3 A8K7S7 O60520 O15383 Q53GG2 Q53GC1 Q6IBI3 |
| Accessions | EAW68337 EAW68338 EAW68339 EAW68340 EAW68341 Q9BUP3 AF039103 AAC39694 AF092095 AAC78331 AI193677 AK130473 AK222969 BAD96689 AK223010 BAD96730 AK292092 BAF84781 AW963626 BC002439 AAH02439 BC015358 AAH15358 BF681178 BP382529 CR456821 CAG33102 DB450790 EU446982 ABZ92511 U69161 AAB84360 NM_001098520 NP_001091990 NM_001098521 NP_001091991 NM_001098522 NP_001091992 NM_001098523 NP_001091993 NM_006410 NP_006401 |
| Function | Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. {ECO:0000269|PubMed:10611237, ECO:0000269|PubMed:11313954, ECO:0000269|PubMed:15282309, ECO:0000269|PubMed:9174052}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15282309}. Nucleus envelope {ECO:0000269|PubMed:15282309}. |
| Tissue Specificity | Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas. {ECO:0000269|PubMed:14695192, ECO:0000269|PubMed:9174052}. |
HTATIP2 - MBS1273636 from MyBioSource
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Human HTATIP2 cDNA clone(NM_001098520.1) - CDFH008864 from Creative Biomart
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Human HTATIP2 cDNA clone(NM_001098521.1) - CDFH008865 from Creative Biomart
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Human HTATIP2 cDNA clone(NM_001098523.1) - CDFH008866 from Creative Biomart
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Human HTATIP2 cDNA clone(NM_001098522.1) - CDFH008867 from Creative Biomart
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Human HTATIP2 ORF Clone(NM_006410.4) - CDCL166636 from Creative Biomart
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Human HTATIP2 ORF Clone(NM_001098520.1) - CDCR346492 from Creative Biomart
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Human HTATIP2 ORF Clone(NM_001098520.1) - CDCR346493 from Creative Biomart
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Human HTATIP2 ORF Clone(NM_001098521.1) - CDCR346494 from Creative Biomart
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Human HTATIP2 ORF Clone(NM_001098521.1) - CDCR346495 from Creative Biomart
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Human HTATIP2 ORF Clone(NM_001098522.1) - CDCR346496 from Creative Biomart
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Human HTATIP2 ORF Clone(NM_001098522.1) - CDCR346497 from Creative Biomart
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Human HTATIP2 ORF Clone(NM_001098523.1) - CDCR346498 from Creative Biomart
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Human HTATIP2 ORF Clone(NM_001098523.1) - CDCR346499 from Creative Biomart
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Human HTATIP2 ORF Clone(NM_001098522.1) - CDCR346496 from Creative biogene
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Human HTATIP2 ORF clone (NM_001098520.1) - CDCL118835 from Creative biogene
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Human HTATIP2 ORF clone (NM_001098523.1) - CDCL118837 from Creative biogene
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Human HTATIP2 ORF clone (NM_001098521.1) - CDCL118839 from Creative biogene
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Human HTATIP2 ORF Clone (BC002439) - CDCS407431 from Creative biogene
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Human HTATIP2 cDNA Clone(NM_001098520.1) - CDFH008864 from Creative biogene
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Human HTATIP2 cDNA Clone(NM_001098521.1) - CDFH008865 from Creative biogene
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Human HTATIP2 cDNA Clone(NM_001098523.1) - CDFH008866 from Creative biogene
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Human HTATIP2 cDNA Clone(NM_001098522.1) - CDFH008867 from Creative biogene
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