GSK3A

Gene Symbol	GSK3A
Entrez Gene	2931
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	glycogen synthase kinase 3 alpha
Other Description	GSK-3 alpha|glycogen synthase kinase-3 alpha|serine/threonine-protein kinase GSK3A
Swissprots	O14959 P49840
Accessions	AAD11986 EAW57114 EAW57115 P49840 BC027984 AAH27984 BC051865 AAH51865 CR749620 CAH18414 D63424 BAA23608 DQ891014 ABM81940 DQ893329 ABM84255 DQ894195 ABM85121 DQ896624 ABM87623 L40027 AAA62432 NM_019884 NP_063937
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establish
Top Pathways	Chemokine signaling pathway, Dopaminergic synapse, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-GSK-3α/β (Ser21/9) (D17D2) Rabbit mAb - 8566 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D17D2

Phospho-GSK-3α (Ser21) (46H12) Mouse mAb - 9337 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (20 western blots) Host Mouse Clonality Monoclonal Clone 46H12

Phospho-GSK-3α (Ser21) (D1G2) Rabbit mAb - 8452 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D1G2

Phospho-GSK-3α (Ser21) (36E9) Rabbit mAb - 9316 from Cell Signaling Technology Prices $109.00, $307.00, $719.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots) Host Rabbit Clonality Monoclonal Clone 36E9

Phospho-GSK-3α/β (Ser21/9) Antibody - 9331 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Phospho-GSK-3α (Ser21) (27E5) Mouse mAb - 5090 from Cell Signaling Technology Host Mouse Clonality Monoclonal Clone 27E5

Phospho-GSK-3α/β (Ser21/9) (37F11) Rabbit mAb (GSK-3α Preferred) - 9327 from Cell Signaling Technology Prices $307.00, $719.00 Sizes 100 µl (10 western blots), 300 µl (30 western blots) Host Rabbit Clonality Monoclonal Clone 37F11

GSK-3α/β (D75D3) Rabbit mAb - 5676 from Cell Signaling Technology Prices $109.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D75D3

GSK-3α (D80D1) XP ® Rabbit mAb - 4818 from Cell Signaling Technology Prices $277.00 Sizes 100 µl (100 assays) Host Rabbit Clonality Monoclonal Clone D80D1

GSK-3α (D80E6) Rabbit mAb - 4337 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D80E6

GSK-3α Antibody - 9338 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Phospho-GSK-3alpha (Ser21) (46H12) Mouse mAb - 5085 from Cell Signaling Technology Host Mouse Clonality Monoclonal Clone 46H12

Phospho-GSK-3alpha/beta (Ser21/9) Antibody - 5080 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

GSK-3α (R-20) - sc-1846 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GSK-3α (H-75) - sc-7879 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

GSK-3α (C-20) - sc-1844 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GSK-3α (H-12) - sc-5264 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

GSK-3α (B-8) - sc-166116 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

GSK-3α (9D5G1) - sc-81166 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

GSK-3α (10C1) - sc-81463 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

GSK-3α/β (0011-A) - sc-7291 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

GSK-3α/β (1H8) - sc-56913 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

p-GSK-3α (E-2) - sc-365483 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

p-GSK-3α (Ser 21) - sc-16308 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

p-GSK-3α (8.Ser 21) - sc-293134 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

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