| Gene Symbol |
PPP1R13B
|
| Entrez Gene |
23368
|
| Alt Symbol |
ASPP1, p53BP2-like, p85
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, regulatory subunit 13B
|
| Other Description |
apoptosis-stimulating of p53 protein 1|apoptosis-stimulating protein of p53, 1|protein phosphatase 1 regulatory subunit 13B|protein phosphatase 1, regulatory (inhibitor) subunit 13B
|
| Swissprots |
Q96KQ4 B2RMX5 O94870
|
| Accessions |
CCQ43503 EAW81845 EAW81846 EAW81847 Q96KQ4 AB018314 BAA34491 AJ318887 CAC83011 AK021580 AK023188 BAG51166 AK125374 AK125913 BAC86342 AK307149 AW295594 BC035446 BC047639 BC136527 AAI36528 DB461586 XM_005267487 XP_005267544 XM_011536592 XP_011534894 XM_011536593 XP_011534895 XM_011536594 XP_011534896 XM_011536595 XP_011534897 XM_011536596 XP_011534898 XM_011536597 XP_011534899 XM_011536598 XP_011534900 XR_245676 XR_943410 XR_943411 XR_943412 XR_943413 NM_015316 NP_056131
|
| Function |
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11684014}. Nucleus {ECO:0000269|PubMed:11684014}. Note=Predominantly cytoplasmic. Some fraction is nuclear.
|
| Tissue Specificity |
Reduced expression in breast carcinomas expressing a wild-type TP53 protein. {ECO:0000269|PubMed:11684014}.
|
![Western Blot: ASPP1 Overexpression Lysate (Adult Normal) [NBP2-10288] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ASPP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7105_ASPP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10288-img0001.jpg)