Gene Symbol | PPP1R13B |
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Entrez Gene | 23368 |
Alt Symbol | ASPP1, p53BP2-like, p85 |
Species | Human |
Gene Type | protein-coding |
Description | protein phosphatase 1, regulatory subunit 13B |
Other Description | apoptosis-stimulating of p53 protein 1|apoptosis-stimulating protein of p53, 1|protein phosphatase 1 regulatory subunit 13B|protein phosphatase 1, regulatory (inhibitor) subunit 13B |
Swissprots | Q96KQ4 B2RMX5 O94870 |
Accessions | CCQ43503 EAW81845 EAW81846 EAW81847 Q96KQ4 AB018314 BAA34491 AJ318887 CAC83011 AK021580 AK023188 BAG51166 AK125374 AK125913 BAC86342 AK307149 AW295594 BC035446 BC047639 BC136527 AAI36528 DB461586 XM_005267487 XP_005267544 XM_011536592 XP_011534894 XM_011536593 XP_011534895 XM_011536594 XP_011534896 XM_011536595 XP_011534897 XM_011536596 XP_011534898 XM_011536597 XP_011534899 XM_011536598 XP_011534900 XR_245676 XR_943410 XR_943411 XR_943412 XR_943413 NM_015316 NP_056131 |
Function | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11684014}. Nucleus {ECO:0000269|PubMed:11684014}. Note=Predominantly cytoplasmic. Some fraction is nuclear. |
Tissue Specificity | Reduced expression in breast carcinomas expressing a wild-type TP53 protein. {ECO:0000269|PubMed:11684014}. |
ASPP1 CRISPR/Cas9 KO Plasmid (h) - sc-404330 from Santa Cruz Biotechnology
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ASPP1 HDR Plasmid (h) - sc-404330-HDR from Santa Cruz Biotechnology
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ASPP1 Double Nickase Plasmid (h) - sc-404330-NIC from Santa Cruz Biotechnology
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ASPP1 Double Nickase Plasmid (h2) - sc-404330-NIC-2 from Santa Cruz Biotechnology
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ASPP1 CRISPR Activation Plasmid (h) - sc-404330-ACT from Santa Cruz Biotechnology
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ASPP1 CRISPR Activation Plasmid (h2) - sc-404330-ACT-2 from Santa Cruz Biotechnology
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ASPP1 Lentiviral Activation Particles (h) - sc-404330-LAC from Santa Cruz Biotechnology
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ASPP1 Lentiviral Activation Particles (h2) - sc-404330-LAC-2 from Santa Cruz Biotechnology
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ASPP1 siRNA (h) - sc-60214 from Santa Cruz Biotechnology
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ASPP1 shRNA Plasmid (h) - sc-60214-SH from Santa Cruz Biotechnology
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ASPP1 shRNA (h) Lentiviral Particles - sc-60214-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136641 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0535 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0537 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0536 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17262 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17262 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09171 from Sigma-Aldrich
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PPP1R13B siRNA (Human) - CRH8216 from Cohesion Biosciences
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shRNA set against Human Ppp1r13b (NM_015316.2) - SHH381044 from Creative biogene
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shRNA set against Human PPP1R13B(NM_015316.2) - SHR133206 from Creative biogene
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PPP1R13B shRNA Plasmid (Human) - CHH8216 from Cohesion Biosciences
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PPP1R13B miRNA 3'UTR clone - MiUTR1H-08174 from Creative biogene
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