| Gene Symbol | PPP1R13B |
|---|---|
| Entrez Gene | 23368 |
| Alt Symbol | ASPP1, p53BP2-like, p85 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 1, regulatory subunit 13B |
| Other Description | apoptosis-stimulating of p53 protein 1|apoptosis-stimulating protein of p53, 1|protein phosphatase 1 regulatory subunit 13B|protein phosphatase 1, regulatory (inhibitor) subunit 13B |
| Swissprots | Q96KQ4 B2RMX5 O94870 |
| Accessions | CCQ43503 EAW81845 EAW81846 EAW81847 Q96KQ4 AB018314 BAA34491 AJ318887 CAC83011 AK021580 AK023188 BAG51166 AK125374 AK125913 BAC86342 AK307149 AW295594 BC035446 BC047639 BC136527 AAI36528 DB461586 XM_005267487 XP_005267544 XM_011536592 XP_011534894 XM_011536593 XP_011534895 XM_011536594 XP_011534896 XM_011536595 XP_011534897 XM_011536596 XP_011534898 XM_011536597 XP_011534899 XM_011536598 XP_011534900 XR_245676 XR_943410 XR_943411 XR_943412 XR_943413 NM_015316 NP_056131 |
| Function | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11684014}. Nucleus {ECO:0000269|PubMed:11684014}. Note=Predominantly cytoplasmic. Some fraction is nuclear. |
| Tissue Specificity | Reduced expression in breast carcinomas expressing a wild-type TP53 protein. {ECO:0000269|PubMed:11684014}. |