Gene Symbol | PTGR1 |
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Entrez Gene | 22949 |
Alt Symbol | LTB4DH, PGR1, ZADH3 |
Species | Human |
Gene Type | protein-coding |
Description | prostaglandin reductase 1 |
Other Description | 15-oxoprostaglandin 13-reductase|NADP-dependent leukotriene B4 12-hydroxydehydrogenase|PRG-1|leukotriene B4 12-hydroxydehydrogenase|zinc binding alcohol dehydrogenase domain containing 3 |
Swissprots | B4DPK3 A8K0N2 Q14914 Q9H1X6 Q8IYQ0 F5GY50 |
Accessions | EAW59074 EAW59075 EAW59076 EAW59077 EAW59078 Q14914 AA876375 AK091948 AK289597 BAF82286 AK298379 BAG60615 AK309450 AK309866 BC035228 AAH35228 D49387 BAA08382 XM_011518394 XP_011516696 XM_011518395 XP_011516697 XR_929738 NM_001146108 NP_001139580 NM_001146109 NP_001139581 NM_012212 NP_036344 |
Function | Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. {ECO:0000250}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | High expression in the kidney, liver, and intestine but not in leukocytes. {ECO:0000269|PubMed:8576264}. |
Human PTGR1 full length protein - ab130018 from Abcam
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PGR1 / GPR153 Antibody Blocking Peptide - LS-E4259 from LifeSpan Bioscience
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PGR1 / GPR153 Antibody Blocking Peptide - LS-E28689 from LifeSpan Bioscience
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PGR1 / GPR153 Antibody Blocking Peptide - LS-E28690 from LifeSpan Bioscience
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PGR1 / GPR153 Antibody Blocking Peptide - LS-E28471 from LifeSpan Bioscience
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PTGR1 / LTB4DH Antibody Blocking Peptide - LS-E8052 from LifeSpan Bioscience
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PTGR1 / LTB4DH Antibody Blocking Peptide - LS-E19786 from LifeSpan Bioscience
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Recombinant Human PGR1 Protein - H00022949-Q01 from Novus Biologicals
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Recombinant Human PGR1 Protein - NBP1-98962 from Novus Biologicals
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Recombinant Human PGR1 Protein - NBP1-98897 from Novus Biologicals
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PTGR1-Antibody-Center-Blocking-peptide - BP5941c from Abgent, a WuXi AppTec company
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Human PTGR1 protein - orb169112 from Biorbyt
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LTB4DH Blocking Peptide - 33R-9791 from Fitzgerald
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PTGR1 protein (His tag) - 80R-2378 from Fitzgerald
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Prostaglandin reductase 1 (1-329, His-tag) - AR50459PU-N from Acris Antibodies
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Prostaglandin reductase 1 (1-329, His-tag) - AR50459PU-S from Acris Antibodies
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Prostaglandin reductase 1 - H00022949-Q01-10 from Acris Antibodies
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Prostaglandin reductase 1 - H00022949-Q01-25 from Acris Antibodies
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Prostaglandin reductase 1 - P5854 from Acris Antibodies
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PTGR1, 1-329aa, Human, His tag, E.coli, - 01-P1635 from ARP American Research Products
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PTGR1 fusion protein - Ag4196 from Proteintech Group
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PTGR1 Human - ENPS-640 from NeoScientific
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Recombinant Human Prostaglandin Reductase 1 Enzyme - BP002772-ENZ-633 from Syd Labs
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Recombinant Human Prostaglandin Reductase 1, His-tagged - PTGR1-2520H from Creative Biomart
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Recombinant Human PTGR1, GST-tagged - PTGR1-2048H from Creative Biomart
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