Gene Symbol | PTGR1 |
---|---|
Entrez Gene | 22949 |
Alt Symbol | LTB4DH, PGR1, ZADH3 |
Species | Human |
Gene Type | protein-coding |
Description | prostaglandin reductase 1 |
Other Description | 15-oxoprostaglandin 13-reductase|NADP-dependent leukotriene B4 12-hydroxydehydrogenase|PRG-1|leukotriene B4 12-hydroxydehydrogenase|zinc binding alcohol dehydrogenase domain containing 3 |
Swissprots | B4DPK3 A8K0N2 Q14914 Q9H1X6 Q8IYQ0 F5GY50 |
Accessions | EAW59074 EAW59075 EAW59076 EAW59077 EAW59078 Q14914 AA876375 AK091948 AK289597 BAF82286 AK298379 BAG60615 AK309450 AK309866 BC035228 AAH35228 D49387 BAA08382 XM_011518394 XP_011516696 XM_011518395 XP_011516697 XR_929738 NM_001146108 NP_001139580 NM_001146109 NP_001139581 NM_012212 NP_036344 |
Function | Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. {ECO:0000250}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | High expression in the kidney, liver, and intestine but not in leukocytes. {ECO:0000269|PubMed:8576264}. |
LTB4DH CRISPR/Cas9 KO Plasmid (h) - sc-409232 from Santa Cruz Biotechnology
|
||||||||
LTB4DH HDR Plasmid (h) - sc-409232-HDR from Santa Cruz Biotechnology
|
||||||||
LTB4DH Double Nickase Plasmid (h) - sc-409232-NIC from Santa Cruz Biotechnology
|
||||||||
LTB4DH Double Nickase Plasmid (h2) - sc-409232-NIC-2 from Santa Cruz Biotechnology
|
||||||||
LTB4DH CRISPR Activation Plasmid (h) - sc-409232-ACT from Santa Cruz Biotechnology
|
||||||||
LTB4DH CRISPR Activation Plasmid (h2) - sc-409232-ACT-2 from Santa Cruz Biotechnology
|
||||||||
LTB4DH Lentiviral Activation Particles (h) - sc-409232-LAC from Santa Cruz Biotechnology
|
||||||||
LTB4DH Lentiviral Activation Particles (h2) - sc-409232-LAC-2 from Santa Cruz Biotechnology
|
||||||||
LTB4DH siRNA (h) - sc-92772 from Santa Cruz Biotechnology
|
||||||||
LTB4DH shRNA Plasmid (h) - sc-92772-SH from Santa Cruz Biotechnology
|
||||||||
LTB4DH shRNA (h) Lentiviral Particles - sc-92772-V from Santa Cruz Biotechnology
|
||||||||
PGR1 RNAi - H00022949-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU072611 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17674 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17674 from Sigma-Aldrich
|
||||||||
PTGR1 siRNA (Human) - CRH7894 from Cohesion Biosciences
|
||||||||
shRNA set against Human PTGR1 (NM_012212.3) - SHH386112 from Creative biogene
|
||||||||
Human PTGR1 siRNA - orb268396 from Biorbyt
|
||||||||
PTGR1 shRNA Plasmid (Human) - CHH7894 from Cohesion Biosciences
|
||||||||
PTGR1 miRNA 3'UTR clone - MiUTR3H-04016 from Creative biogene
|
||||||||
PTGR1 miRNA 3'UTR clone - MiUTR3H-04017 from Creative biogene
|
||||||||
PTGR1 miRNA 3'UTR clone - MiUTR3H-04018 from Creative biogene
|